Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

By A. Bafico, Guizhong Liu, A. Yaniv, A. Gazit, S. Aaronson. Nature Cell Biology, 2001

819 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2379b37b0ccc5662792a3b4cb3d39e047bfc8e29

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In Immunology

1. R. Nusse
2. Hans Clevers
3. David M. Sabatini

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. K. Guan
5. Xi He
6. S. Angers
7. David M. Sabatini
8. Z. Steinhart

Citations in the corpus

• Secreted and transmembrane wnt inhibitors and activators. (2013, neutral): “7 nM (Bafico et al. 2001; Mao et al. 2001; Semenov et al. 2001).”
• TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. (2006, background): “DKK1 binds the Wnt coreceptor LRP5/6 and inhibits canonical Wnt signaling (Bafico et al., 2001; Mao et al., 2001).”
• Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “GENES & DEVELOPMENT 19:877–890 © 2005 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/05; www.genesdev.org 877 secreted factors such as Dickkopfs (Bafico et al. 2001), Wnts may nonetheless form a complex with Fz, triggering Tcf/ -catenin-independent cellular responses such as increased calcium”
• The Wnt signaling pathway in development and disease. (2004, background): “It binds to LRP with high affinity (Bafico et al. 2001, Mao et al. 2001a, Semenov et al. 2001) and to another class of transmembrane molecules, the Kremens (Mao & Niehrs 2003, Mao et al. 2002).”
• Wnt signaling in development and tissue homeostasis (2018, background): “How Wnts co-engage Frizzled and LRP5/6 co-receptors, and the precise nature of the activated complex, also remains poorly characterized.”
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way (2004, background): “…bind Wnts, including the sFRP (secreted Frizzled-related protein) family, Wif1 (Wnt i hibitory factor 1) and XenopusCerberus (Semenov and He, 2003), Dkk1 does not bind Wnt but is a high affinity ligand for Lrp6 (Kd=0.3-0.5 nM) and Lrp5 (Bafico et al., 2001; Mao et al., 2001a; Semenov et al., 2001).”
• Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β‐Catenin Signaling (2009, background): “Dkk1 antagonism on Wnt/b-catenin signaling was identified originally through its binding with Lrp6.((35,36)) Sclerostin bound to both Lrp5 and Lrp6, and particularly, it was”
• Secreted antagonists of the Wnt signalling pathway (2003, background): “However, unlike sFRPs, Dkk-1 prevents activation of the Wnt signalling pathway by binding to LRP5/6 rather than to Wnt proteins (Bafico et al., 2001; Mao, B. et al., 2001; Semenov et al., 2001).”