Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.

By J. Fruebis, T. Tsao, S. Javorschi, D. Ebbets-reed, M. Erickson, F. Yen, B. Bihain, H. Lodish. Proceedings of the National Academy of Sciences of the United States of America, 2001

2,037 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/234a3d3ae6a6a24b0e6004bd4f2bb7303ed4198b

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In Epidemiology

1. H. Fang
2. R. L. Judd
3. P. Scherer
4. Haiming Cao
5. Barry J. Goldstein
6. Rosario Scalia
7. Toshimasa Yamauchi
8. N. Ouchi

In Geriatrics and Gerontology

1. H. Fang
2. R. L. Judd
3. Barry J. Goldstein
4. Rosario Scalia
5. Bruce E. Kemp
6. Mitchell A. Lazar
7. G. Steinberg

In Physiology

1. H. Fang
2. R. L. Judd
3. P. Scherer
4. Haiming Cao
5. G. Steinberg
6. D. Moller
7. F. B. Hu
8. Mitchell A. Lazar

Citations in the corpus

• Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. (2002, background): “Recent studies demonstrated that adiponectin increased fatty acid oxidation (40), augmented insulin action in the muscle and liver, and further improved insulin resistance in lipoatrophic and genetically obese mice, both of which had hypoadiponectinemia (21,22).”
• Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms (2005, background): “Previous studies have shown that adiponectin might have potential utility for the treatment of a variety of chronic diseases including obesit”
• Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. (2007, background): “Adiponectin has been shown to increase the sensitivity of peripheral tissues to insulin, and it has been suggested that the decreased circulating levels of adiponectin in obesity and type 2 diabetes may contribute to the insulin resistance that characterizes both conditions (Berg et al., 2001; Frueb”
• Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. (2003, background): “The infusion of an adiponectin cleavage product containing the globular head of the protein resulted in a decrease in plasma nonesterified fatty acid, along with an increase in muscle lipid oxidation (14).”
• Adiponectin: action, regulation and association to insulin sensitivity (2005, background): “It is suggested that adiponectin plays an important role in lipid metabolism, however, whether FFA regulate adiponectin levels remains unclear.”
• Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. (2003, background): “Interestingly, there is some evidence that adiponectin may participate in fatty acid and energy homeostasis.(23) It is possible that a high production of IL-6 from adipose tissue associated with low production of adiponectin may be involved in obesity-associated insulin resistance through convergent”
• PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. (2001, background): “(43), who found that the administration of the globular domain of ACRP30 increased free fatty acid oxidation and decreased plasma glucose in mice, reflecting an improvement in insulin resistance.”