Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

By Joshua T. Mendell, N. Sharifi, J. Meyers, F. Martínez-Murillo, H. Dietz. Nature Genetics, 2004

899 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/23312c4d8abcceba8801a01575ece53afb80ffd1

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Citations in the corpus

Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “…NMD targets in mammals function in a broad range of cellular processes that include transcription, telomere maintenance, DNA repair, cell growth, intracellular transport (Rehwinkel et al. 2006), and NMD itself (Mendell et al. 2004; Rehwinkel et al. 2005; Wittmann et al. 2006; Chan et al. 2007).”
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro (2005, background): “The mutant genes were transcribed, and not removed by nonsense-mediated mRNA deca”
Regulation of cytoplasmic mRNA decay (2012, background): “Downregulating the essential NMD factor up-frameshift 1 (UPF1) using short interfering RNA (siRNA) upregulates ~5% of properly functioning transcript”
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. (2006, background): “…spliced mRNAs, and upstream open reading frames (uORFs) containing mRNAs as natural targets (Mitrovich and Anderson 2000, 2005; He et al. 2003; Mendell et al. 2004), and, in the case of the vertebrate immune system, mRNAs emanating from out-of-frame gene rearrangements (Li and Wilkinson 1998;…”
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. (2007, methodology): “0 microarrays was performed by the Johns Hopkins University School of Medicine Microarray Core Facility as described (Mendell et al., 2004).”
The highways and byways of mRNA decay (2007, background): “Microarray analysis of the transcriptome in UPF1-depleted mammalian cells identified numerous upregulated normal transcripts, some of which contained upstream ORFs, 3′-UTR introns, frameshifts or other features that mimic a PT”