Synaptic assembly of the brain in the absence of neurotransmitter secretion.

By M. Verhage, A. Maia, J. Plomp, A. Brussaard, J. Heeroma, Hendrika, Vermeer, R. Toonen, R. Hammer, T. Berg and 4 more. Science, 2000

1,365 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/23263f9a64af4aca7bca820df06439157b57fffb

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Citations in the corpus

Is there more to gaba than synaptic inhibition? (2002, result): “Similar results have been reported for Munc18-knockout animal”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Although some experiments indicates that neuronal activity is not necessary for synapse formation during development per se (Varoqueaux et al., 2002; Verhage et al., 2000), activity is majorly involved in regulation of synaptic stabilization or elimination (Varoqueaux et al.”
Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex (2000, background): “However, null alleles and certain point mutations of members of the Sec1 family lead to a block in vesicle fusio”
Secretory granule exocytosis. (2003, background): “Genetic studies have established a general requirement for Sec1-related genes in vesicle fusion in a wide variety of organisms, including yeast (SEC1, SLY1, VPS33, VPS45), plants (KEULE), nematodes (UNC18), flies (ROP), and mice (munc18–1) (32, 303, 800).”
Sec1/Munc18 Proteins: Mediators of Membrane Fusion Moving to Center Stage (2000, background): “In recent years, we that synaptic activity is not needed for the initial estab-have learned that many of the proteins involved in exolishment of synaptic connectivity (Verhage et al., 2000).cytosis belong to families common to all eukaryotic Munc18a (also referred to as n-Sec1 or rbSec1) wascells.”
Maturation and Death of Adult-Born Olfactory Bulb Granule Neurons: Role of Olfaction (2002, background): “This may be followed by an activity-dependent mechanism in which many cells are eliminated by apoptosis (Verhage et al., 2000).”
PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “Disruption of Munc18–1 in mice completely abolishes neurotransmission without affecting SV docking, suggesting a role of Munc18 in a postdocking step (561).”
Cation-chloride cotransporters and neuronal function. (2009, background): “Somewhat surprisingly, synaptogenesis and early brain development are hardly affected in knockout mice where GABA synthesis, vesicular transport, or vesicular release are eliminated (Jin et al., 1999; Varoqueaux et al., 2002; Verhage et al., 2000; Wojcik et al., 2006).”
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle (2013, background): “However, the proposal that Munc18-1 activates fusion met resistance because Munc18-1 binding to closed syntaxin-1 appeared to suggest that Munc18-1 is an inhibitor of fusion (Yang et al., 2000), despite the fact that Munc18-1 is absolutely required for synaptic fusion (Verhage et al., 2000).”
Excitatory actions of gaba during development: the nature of the nurture (2002, background): “Brain assembly, including the formation of layered structures and fibre pathways, does not require transmitter release, and depends on a genetically determined programm”
Genesis of dendritic spines: insights from ultrastructural and imaging studies (2004, background): “However, transgenic and knockout animals are becoming increasingly useful for disentangling the roles of pre- and postsynaptic structure”
Innateness, AlphaZero, and Artificial Intelligence (2018, background): “Even in the absence of synaptic transmission, the primary mechanism by which experience is conveyed to the brain, the basic structure of the newborn brain is preserved (Verhage et al., 2000).”