Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex

By Kira M. S. Misura, R. Scheller, William I. Weis. Nature, 2000

774 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/aef229aa2495a2fdbfe6994e0cddcb143a4f3f9f

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Citations in the corpus

SCOP database in 2002: refinements accommodate structural genomics (2002, background): “53 release, two new structures for the same protein became available (1ez3 and 1dn1) (14,15).”
SNAREs and traffic. (2005, background): “Munc18-1 is believed to bind to Syn1 in its closed conformation involving both the N-terminal Habc region and the SNARE motif, thus modulating its interaction with SNAP-25 and t-SNARE assembly [19,37].”
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle (2013, background): “Katz’s brilliant work built on George Palade’s (1912– 2008) studies on vesicular trafficking (Palay and Palade, 1955) and initiated a series of elegant electrophysiological experiments that characterized the process of synaptic transmission in exquisite detail.”
Molecular machines governing exocytosis of synaptic vesicles (2012, background): “For many years, the molecular mechanism of Munc18 has been shrouded by a paradox because it locks syntaxin-1 in a closed conformation (24,33) (Fig.”
A Syntaxin 1, Gαo, and N-Type Calcium Channel Complex at a Presynaptic Nerve Terminal: Analysis by Quantitative Immunocolocalization (2004, background): “A number of reports have concluded that syntaxin 1 can exist in an open, active configuration, as well as a closed inactive one stabilized by MUNC18 –1 (Hata et al., 1993; Kee et al., 1995; Misura et al., 2000 ).”
Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. (2007, background): “autoinhibited through an interaction of its N-terminal domain with its C-terminal SNARE motif (Misura et al., 2000).”
Sec1/Munc18 Proteins: Mediators of Membrane Fusion Moving to Center Stage (2000, background): “…these proteins are every bit as essential Recently, work from Misura and colleagues has reas the SNAREs for membrane fusion at synapses (re- solved the the three-dimensional crystal structure of the viewed by Halachmi and Lev, 1996; Jahn and Südhof, munc18/syntaxin 1 complex (Misura et al., 2000).”
SNARE-mediated membrane fusion (2001, background): “that competes with the VAMP and SNAP-25 coils for binding of its own carboxy-terminal coil (forming the 'closed' conformation of syntaxin”