Endosomal escape pathways for delivery of biologicals.

By Amir K. Varkouhi, M. Scholte, G. Storm, H. Haisma. Journal of Controlled Release, 2011

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Chapter Five – Progress Towards RNAi-Mediated Insect Pest Management (2014, background): “escape from the endosome becomes a critical step for delivery to the cytoplasm (Varkouhi et al., 2011).”
Basics and recent advances in peptide and protein drug delivery (2013, neutral): “Particles smaller than 300 nm usually do not enter cells through the endosomal pathway, but particles 500– 700 nm are often taken up by endocytosis [172].”
Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “In these systems, membrane-disruptive properties can be obtained by using proteins and peptides [143, 144], polymers [145, 146] or simply by incorporating a high number of ionisable amine groups to exploit the proton sponge effect [117].”
Cell-Penetrating Peptides: From Basic Research to Clinics. (2017, background): “Thus, it should be considered that endosomal escape must be highly efficient to facilitate the early release of therapeutic cargoes from endosomes into the cytosol [131].”