Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans

By Michael A. Nitsche, Walter Paulus. Neurology, 2001

2,562 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/227ee8e23975df61a34d465d6b0dd0eab494a40c

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Citations in the corpus

Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). (2017, background): “A longer stimulation duration (several minutes) induces excitability changes that can last for one hour or more (Nitsche and Paulus, 2001; Nitsche et al., 2003b; Priori, 2003).”
Variability in response to transcranial direct current stimulation of the motor cortex. (2014, positive): “with the anode over motor areas) increased excitability of corticospinal output, as tested using single pulse transcranial magnetic stimulation (TMS), whereas cathodal stimulation had the opposite effect [7].”
Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease (2006, result): “In that study, we proposed that the observed effects were due to an enhancement of the local cortical excitability of the left dorsolateral prefrontal cortex since (i) anodal tDCS induces a membrane effect in the neuron characterized by a neuron depolarization [32] and therefore can increase local e”
Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation (2009, background): “What could the mechanism of tDCS-induced consolidation be? The effect of anodal tDCS on cortical excitability is known to outlast the stimulation period (44, 45).”
Modeling the current distribution during transcranial direct current stimulation. (2006, background): “Long term changes in motor cortex excitability following transcranial direct current stimulation (tDCS) have been recently demonstrated non-invasively in humans (Nitsche and Paulus, 2000, 2001; Priori et al., 1998).”
Transcranial Alternating Current Stimulation Enhances Individual Alpha Activity in Human EEG (2010, background): “Both, tDCS and repetitive trancranial magnetic stimulation (TMS) also lead to aftereffects of up to one hour duration or longer [58,59].”
Physiological Basis of Transcranial Direct Current Stimulation (2011, methodology): “The effects of tDCS are in the majority intracortical (Nitsche and Paulus 2000, 2001; Nitsche, Nitsche, and others 2003).”
The electric field in the cortex during transcranial current stimulation (2013, background): “Long-lasting and polarity-dependent changes in neural excitability of the human cortex are elicited as a result (Nitsche and Paulus, 2000, 2001).”
Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: A basis for high-definition tDCS (2013, background): “tDCS induces lasting biological effects (Edwards et al., 2009; Nitsche and Paulus, 2001) and is being currently explored to treat a range of neuropsychiatric disorders and facilitate rehabilitation, including after stroke (Hummel et al.”
A technical guide to tDCS, and related non-invasive brain stimulation tools (2015, background): “For safety aspects in a strict sense, structural damage of brain tissue can be ruled out for motor cortex stimulation protocols introduced by Nitsche and colleagues (Nitsche and Paulus, 2001; Nitsche et al., 2003).”
Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex (2004, background): “In accordance with previous reports (Nitsche and Paulus, 2001; Nitsche et al., 2003), anodal TDCS induced a long-lasting increase in corticospinal excitability, whereas cathodal TDCS resulted in a sustained decrease in corticospinal excitability.”
Optimization of multifocal transcranial current stimulation for weighted cortical pattern targeting from realistic modeling of electric fields (2013, positive): “The neuromodulatory effect of these fields has been confirmed in many laboratories (Antal et al., 2008; Nitsche and Paulus, 2001, 2000; Terney et al., 2008).”
Level of action of cathodal DC polarisation induced inhibition of the human motor cortex. (2003, methodology): “…in conscious humans (EEG, PET, fMRI, TMS), and we have recently begun to employ some of these to investigate the nature of the DC effect on primary motor and visual cortex (Nitsche and Paulus, 2000, 2001; Rosenkranz et al., 2000; Antal et al., 2001; Baudewig et al., 2001; Liebetanz et al., 2002).”
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. (2005, background): “Interventional tDCS is easy to apply, painless, presents advantages for the design of Sham controls and can influence motor cortical function for up to 90 min (Nitsche and Paulus, 2001).”
Transcranial direct current stimulation: A computer-based human model study (2007, methodology): “Although forms of DC stimulation have been used since the inception of modern electrophysiology (Aldini, 1804), there has been a recent upsurge in interest in tDCS as a tool for neuroscience research (Nitsche and Paulus, 2001; Antal et al., 2003) and for the treatment and assessment of various neuro”
Pharmacological Modulation of Cortical Excitability Shifts Induced by Transcranial Direct Current Stimulation in Humans (2003, background): “…durations were chosen because 4 s of tDCS results in an excitability change during stimulation without producing after-effects, while a stimulation duration of 9–13 min generates after-effects that last for about 1 h after the end of stimulation (Nitsche & Paulus 2000, 2001; Nitsche et al. 2003a).”
Determinants of the induction of cortical plasticity by non‐invasive brain stimulation in healthy subjects (2010, background): “Anodal tDCS of motor cortex typically induces an LTP-like increase in MEP amplitude while cathodal tDCS induces an LTD-like decrease (Nitsche & Paulus, 2001; Nitsche et al. 2003).”