Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4

By B. Feys, L. Moisan, M. Newman, J. Parker. EMBO Journal, 2001

641 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/22659fa9fdc1302ce3e539c99fc4077ee8d712fb

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Citations in the corpus

The salicylic acid loop in plant defense. (2003, background): “The eds1 and phytoalexin deficient4 (pad4) mutant alleles compromise SA synthesis in plant–pathogen interactions [21 ,22] and in constitutive SA-signaling mutants [23,24].”
Molecular strategies of plant defense and insect counter‐defense (2005, background): “Lipase-like proteins, EDS1 and PAD4, directly interact with each other to control SA accumulation, while EDS1 is also engaged early in the hypersensitive response (Feys et al., 2001).”
Plant immunity: the EDS1 regulatory node. (2005, background): “PAD4, which encodes a protein that interacts with EDS1 in vivo [7], was first discovered among several mutants in a cleverly conceived screen for enhanced disease susceptibility to low doses of virulent Psm [8].”
Salicylic Acid Biosynthesis and Metabolism (2011, background): “Sequence analyses have revealed that EDS1, PAD4, and SAG101 share homology in a novel C-terminal domain, originally designated EP for EDS1-PAD4-specific (Feys et al, 2001; 2005).”
Stress response, cell death and signalling: the many faces of reactive oxygen species (2003, background): “The Arabidopsis EDS4 and PAD4 genes, which encode lipase-like proteins, are also required for pathogen resistance and affect the HR (Feys et al. 2001, Rusterucci et al. 2001).”
Magical mystery tour: Salicylic acid signalling (2015, background): “The exogenous application of SA can rescue defence gene induction in these mutants (Falk et al., 1999; Feys et al., 2001; Zhou et al., 1998).”
Harpin-elicited hypersensitive cell death and pathogen resistance require the NDR1 and EDS1 genes (2003, background): “The signal components EDS1 and NDR1, which are required for the function of some R genes [1,8,26,27,41, 47], also are involved in R-mediated SAR.”
Understanding the functions of plant disease resistance proteins. (2003, background): “syringaeandPeronospora parasiticaconditioned by the same spectrum of TIR-NBS-LRRRgenes (58).”
Salicylic Acid, a multifaceted hormone to combat disease. (2009, background): “rescue defense gene induction in eds1 and pad4 mutants and induce expression of EDS1 and PAD4 in wt plants (50, 52, 237), arguing that EDS1 and PAD4 lie upstream of SA and are positively feedback regulated by SA (Figure 2).”
Priming in plant-pathogen interactions. (2002, background): “It has been proposed that EDS1 takes part in the amplification of defence responses, possibly by associating with PAD4 [ 40 ].”
Arabidopsis PEN3/PDR8, an ATP Binding Cassette Transporter, Contributes to Nonhost Resistance to Inappropriate Pathogens That Enter by Direct Penetration[W][OA] (2006, background): “Although EDS1 and NahG affect the functioning of the SA pathway, they both have additional poorly characterized but SA-independent effects on resistance (Feys et al., 2001; Heck et al., 2003; van Wees and Glazebrook, 2003).”
Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. (2005, background): “HR does not occur as rapidly as in wild-type plants, and hyphae spread ahead of a trailing necrosis, culminating in sparse sporulation (44).”
The plant vascular system: evolution, development and functions. (2013, background): “Some of the Arabidopsis ecotypes express two functionally redundant isoforms of EDS1 which interact with each other as well as with the structurally similar PAD4 and SAG101 proteins (Feys et al. 2001; He and Gan 2002; Feys et al. 2005; Garcı́a et al. 2010; Zhu et al. 2011).”