Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

By E. Kurt-Jones, Lana Popova, Laura A. Kwinn, L. Haynes, L. Jones, R. Tripp, E. Walsh, M. Freeman, D. Golenbock, L. Anderson and 1 more. Nature Immunology, 2000

1,830 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/22211f6352891a255928afb0a9f61241d1ecde78

How researchers see this paper

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In Epidemiology

1. Shizuo Akira
2. R. Medzhitov
3. O. Takeuchi
4. T. Mogensen
5. K. Takeda
6. Satoshi Uematsu
7. S. Ghosh
8. R. Randall

In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. T. Mogensen
4. S. Ghosh
5. O. Takeuchi
6. K. Takeda
7. Taro Kawai
8. M. Hayden

Citations in the corpus

• Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003, background): “RSV and MMTV signal through TLR4 (28, 42), while measles virus, a member of the FIG.”
• Recognition of microbial infection by Toll-like receptors. (2003, background): “By contrast, these mice had little defect in their responses to influenza virus infection [44,45].”
• NF-κB and the immune response (2006, background): “For example, TLR4 may recognize respiratory syncytial virus (RSV) F protein (Kurt-Jones et al., 2000).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “Whilst the biological significance of induction of IFN in response to LPS remains unclear, there is evidence that respiratory syncytial virus (RSV) can induce IFN synthesis through TLR4 via recognition of its F protein (Kurt-Jones et al., 2000; Haynes et al., 2001).”
• Pathogen recognition and innate immunity. (2006, positive): “For instance, the fusion (F) protein from RSV has been identified as a viral component that activates TLR4 (Kurt-Jones et al., 2000).”
• Toll-like receptors and innate immunity (2006, background): “The fusion protein from respiratory syncytial virus (RSV) is recognized by TLR4 [32].”