Homeostasis and Inflammation in the Intestine

By W. Garrett, Jeffrey I. Gordon, Laurie H. Glimcher. Cell, 2010

784 citations recorded by the source corpus.

The gut is home to our largest collection of microbes. The ability of the immune system to co-evolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain an equilibrium between a host and its microbiota has negative consequences for both intestinal and systemic health. In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost.

Subfields: Gastroenterology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/217f84a8b52084b29b3e85359cca7eb0d2ca1d31

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Citations in the corpus

Adipocyte Inflammation is Essential for Healthy Adipose Tissue Expansion and Remodeling (2014, background): “This is based on the observation that gut flora can be transferred from mouse to mouse and affect the pathogenesis of obesity and hepatic steatosis (Garrett et al., 2010; Henao-Mejia et al., 2012).”
The immune system and the gut microbiota: friends or foes? (2010, background): “Recent reviews have highlighted how the microbiota elicits innate and adaptive immune mechanisms that cooperate to protect the host and maintain intestinal homeostasi”
Chapter 12: Human Microbiome Analysis (2012, background): “Indeed, Nobel Prize winner Ilya Mechnikov famously named Lactobacillus bulgaricus, a primary yogurt-producing bacterium, for its apparent contribution to the longevity of yogurt-consuming Bulgarians [158], and despite a degree of unfortunate popular hype, the potential health benefits of a variety o”
Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish. (2018, background): “Dysbiosis of the gut microbiota has generally been associated with several physiological changes such as colitis and abnormal behavior (Sartor, 2006; Garrett et al., 2010; Glenny et al., 2017).”
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition (2014, background): “Over millennia, many of these microbes have evolved to coexist within the host by assuming a symbiotic role to avoid elimination by the immune system (2).”
Characterization of the Gut Microbiome Using 16S or Shotgun Metagenomics (2016, background): “TECHNOLOGY REPORT published: 20 April 2016 doi: 10.3389/fmicb.2016.00459 Frontiers in Microbiology | www.frontiersin.org 1 April 2016 | Volume 7 | Article 459 Edited by: Martha E. Trujillo, Universidad de Salamanca, Spain Reviewed by: Ranjit Kumar, University of Alabama at Birmingham, USA Henning Se”
The microbiome and human cancer (2021, background): “Given that the intestinal barrier offers the largest host-microbial interface and greatest microbial diversity, investigations on the potential impact of the microbiota in oncogenesis or cancer prognosis have primarily focused on this barrier (107).”
IgT, a primitive immunoglobulin class specialized in mucosal immunity (2010, background): “More particularly, as the gut lumen is rich both in bacterial products derived from commensal bacteria (such as lipopolysaccharide and DNA), as well as food antigens, it is believed that a critical aspect in preserving its mucosal homeostasis relies on mechanisms directed at avoiding or inhibiting a”
Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “Paneth cells, goblet cells, absorptive cells, and enteroendocrine cells are the four major secretory cell types in IEC populations [105], and Paneth cells play an essential role in controlling bacteria via the secretion of antimicrobial peptides [106].”
Stress, Inflammation, and Defense of Homeostasis (2014, background): “For example, cells with a very high secretory demand, such as plasma cells and various exocrine and endocrine cells, experience a chronic ER stress response (Garrett et al., 2010), while kidney tubular epithelial cells experience continuous osmotic stress (Neuhofer and Beck, 2005).”