IgT, a primitive immunoglobulin class specialized in mucosal immunity

By Yong‐An Zhang, I. Salinas, Jun Li, D. Parra, S. Bjork, Zhen Xu, S. Lapatra, J. Bartholomew, J. Sunyer. Nature Immunology, 2010

880 citations recorded by the source corpus.

Teleost fish are the most primitive bony vertebrates that contain immunoglobulins. In contrast to mammals and birds, these species are devoid of immunoglobulin A (IgA) or a functional equivalent. This observation suggests that specialization of immunoglobulin isotypes into mucosal and systemic responses took place during tetrapod evolution. Challenging that paradigm, here we show that IgT, an immunoglobulin isotype of unknown function, acts like a mucosal antibody. We detected responses of rainbow trout IgT to an intestinal parasite only in the gut, whereas IgM responses were confined to the serum. IgT coated most intestinal bacteria. As IgT and IgA are phylogenetically distant immunoglobulins, their specialization into mucosal responses probably occurred independently by a process of convergent evolution.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/341c6a9901335e749ea358e4c76cdeb352df67b3

How researchers see this paper

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In Immunology

1. M. Esteban
2. S. Hoseinifar
3. I. Salinas
4. J. Sunyer
5. A. Cuesta
6. Yun‐Zhang Sun
7. L. Ribas
8. F. Piferrer

Citations in the corpus

• Mucosal immunoglobulins and B cells of Teleost fish (2011, methodology): “It has been shown that a majority of gut commensal bacteria are prevalently coated with sIgT and to a lesser degree with sIgM (Zhang et al., 2010).”
• Prebiotics and Fish Immune Response: A Review of Current Knowledge and Future Perspectives (2015, background): “Functions of this system appear to be related with the ability to trap antigens and release IgT and IgM involved in responses against several pathogens (Zhang et al., 2010; Salinas et al., 2011; Xu et al., 2013).”
• The zebrafish (Danio rerio) as a model organism, with emphasis on applications for finfish aquaculture research (2014, background): “Although it has been recently demonstrated that fish possess an important component of adaptive immunity related to different monomeric and tetrameric immunoglobulins (Zhang et al. 2010), the response of fish to immune challenges is strongly based on the innate immune response (Tort et al.”
• An Overview of the Immunological Defenses in Fish Skin (2012, background): “[221] Y.”