The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.

By M. Neves-Pereira, E. Mundo, P. Muglia, N. King, F. Macciardi, J. Kennedy. American Journal of Human Genetics, 2002

634 citations recorded by the source corpus.

Subfields: Clinical Psychology, Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/213babddf0d4a1e12957566384c7c58c42dc1f9a

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In Clinical Psychology

In Cognitive Neuroscience

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Eero Castrén

Citations in the corpus

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons (2004, background): “…to neuropsychiatric disorders, including Alzheimer's disease (Ventriglia et al., 2002), Parkinson's disease (Momose et al., 2002), bipolar disorder (Neves-Pereira et al., 2002; Sklar et al., 2002), depression (Sen et al., 2003), eating disorder (Ribases et al., 2003), and obsessive compulsive…”
The genetics of schizophrenia and bipolar disorder: dissecting psychosis (2005, methodology): “Regions reported as genome-wide suggestive according to the criteria of Lander and Kruglyak 11 are shown in italics. adult bipolar samples 121 122 and one is with a small childhood onset sample.”
Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “This polymorphism — which was identified from a single nucleotide polymorphism screen — is caused by a single amino-acid change, from valine (Val) to methionine (Met), at position 66 in the pro-domain of the BDNF protei”
Major depressive disorder. (2008, neutral): “ders [39].”
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. (2008, background): “…not only perform less well in tests of learning and memory but also have increased susceptibility to a number of neuropyschiatric disorders, including depression, eating disorders, and bipolar disorder (Neves-Pereira et al., 2002; Ribases et al., 2003, 2004; Sen et al., 2003; Sklar et al., 2002).”
Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease (2010, positive): “, 2004); mood disorders (Neves-Pereira et al., 2002; Sklar et al., 2002; Schumacher et al., 2005; Strauss et al., 2005), neurodegenerative diseases such Huntington's Disease (Zuccato et al.”
New insights into BDNF function in depression and anxiety (2007, result): “Association studies with this polymorphism have been variable, but most analyses have suggested that the Met allele is protective for bipolar disorde”
The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, result): “Although initial studies indicated an association with, among others, bipolar disorder (Neves-Pereira et al., 2002; Sklar et al., 2002), subsequent meta-analyses have not found evidence for the association between bdnf Val66Met polymorphism and depression (Gratacos et al.”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “…val66met polymorphism have suggested that the met allele is protective for anxiety (Lang et al, 2005; Hunnerkopf et al, 2007) depression (Schumacher et al, 2005; Strauss et al, 2005; Frodl et al, 2007), but see Jiang et al (2005), and bipolar disorder (Neves-Pereira et al, 2002; Sklar et al, 2002).”