Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation.

By Markus Stein, R. Rappuoli, A. Covacci. Proceedings of the National Academy of Sciences of the United States of America, 2000

630 citations recorded by the source corpus.

Subfields: Immunology, Small Animals, Surgery

View Paper: https://www.semanticscholar.org/paper/20be8954da4e5227cb668d7999d3b271f3c78199

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Peek
2. Keith T. Wilson
3. Lydia E. Wroblewski
4. E. Kuipers
5. A. V. van Vliet
6. J. G. Kusters
7. Martin J. Blaser
8. Masanori Hatakeyama

In Small Animals

1. R. Peek
2. E. Kuipers
3. A. V. van Vliet
4. J. G. Kusters
5. Masanori Hatakeyama

In Surgery

1. R. Peek
2. Martin J. Blaser
3. Keith T. Wilson
4. Lydia E. Wroblewski
5. E. Kuipers
6. A. V. van Vliet
7. J. G. Kusters
8. Masanori Hatakeyama

Citations in the corpus

• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “tyrosine-alanine (EPIYA) motifs and induces cell morphological changes, initially termed “the hummingbird phenotype,” which are associated with increased cellular migration (20, 226, 279, 292, 293) (see “CagA phosphorylation-dependent host cell signaling”).”
• Helicobacter pylori and gastrointestinal tract adenocarcinomas (2002, background): “pylori into the epithelial cell, where it undergoes tyrosine phosphorylation — a process that is associated with dephosphorylation of host-cell protein”
• Oncogenic mechanisms of the Helicobacter pylori CagA protein (2004, background): “The morphological change is also associated with increased cell motility known as cell scattering and is preceded by the phosphorylation of Cag”
• Pathogenicity Islands in Bacterial Pathogenesis (2004, background): “Work by several groups has demonstrated that the translocation of CagA into target cells is required for these phenotypes (8, 11, 262, 316, 338).”
• Pathogenesis of Helicobacter pylori Infection (2006, background): “Tyrosine phosphorylation occurs within the CagA EPIYA motif and is required for the binding of CagA to SHP-2 (27, 594, 636).”