Oncogenic mechanisms of the Helicobacter pylori CagA protein

By Masanori Hatakeyama. Nature Reviews. Cancer, 2004

772 citations recorded by the source corpus.

Subfields: Immunology, Small Animals, Surgery

View Paper: https://www.semanticscholar.org/paper/1219df41ea08660a66610712bacdb7b70b5593ae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Y. Yamaoka
2. R. Peek
3. B. Goodman
4. H. Gardner
5. Keith T. Wilson
6. Lydia E. Wroblewski
7. E. Kuipers
8. A. V. van Vliet

In Small Animals

1. Y. Yamaoka
2. B. Goodman
3. H. Gardner
4. R. Peek
5. E. Kuipers
6. A. V. van Vliet
7. J. G. Kusters
8. Masanori Hatakeyama

In Surgery

1. Y. Yamaoka
2. R. Peek
3. B. Goodman
4. H. Gardner
5. Keith T. Wilson
6. Lydia E. Wroblewski
7. E. Kuipers
8. A. V. van Vliet

Citations in the corpus

• Mechanisms of disease: Helicobacter pylori virulence factors (2010, background): “It has now become more common to name the first repeat region as EPIYA-A and EPIYA-B segments and to name the second repeat region as EPIYA-C or EPIYA-D segments for Western and East Asian strains, respectively”
• Biogenesis, architecture, and function of bacterial type IV secretion systems. (2005, background): “The reader is referred to recent excellent reviews for more comprehensive information (10, 23, 39, 42, 51, 64, 107, 133).”
• Pathogenesis of Helicobacter pylori Infection (2006, background): “The details of these specific interactions have been the subject of many research papers; these details and their implications are discussed in several recent reviews (64, 260, 454), but they go beyond the scope of this review.”
• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “Phospho-CagA activates a eukaryotic tyrosine phosphatase (SHP-2), leading to sustained activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), Crk adaptor (133), and C-terminal Src kinase, in a tyrosine phosphorylation-dependent manner in which East Asian A-B-Dtype CagA exhibits stron”
• Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse (2008, background): “Tyrosine-phosphorylated CagA then specifically binds to and aberrantly activates SHP-2 tyrosine phosphatase (9, 14), a bona fide oncoprotein whose gain-of-function mutations are associated with human malignancies (13).”
• The microbiome and cancer (2018, background): “Once inside the cell, CagA dysregulates SHP2, a host oncoprotein, leading to uncontrolled cell growth and motility [61].”
• Gastric cancer: a comprehensive review of current and future treatment strategies (2020, background): “CagA is first integrated into the cell through the Type IV secretion system and becomes pathogenetic by activating a signaling cascade, either SHP2, Abl or Src kinases, within the gastric cancer cell depending on its post-translational modifications (17).”