A Stem Cell Molecular Signature

By N. Ivanova, J. Dimos, C. Schaniel, J. Hackney, K. Moore, Ihor R. Lemischka. Science, 2002

1,630 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/20457c18e40da7891ed9e965695f05640aa1c031

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Citations in the corpus

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. (2003, background): “The comparison between mouse and human orthologs up-regulated in hematopoietic stem cells, in the same experimental system, showed a 39% overlap, representing the stem molecular traits conserved between the two species (Ivanova et al. 2002).”
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation (2009, background): “Indeed, previous gene expression profiles have confirmed the expression of these critical factors in HSCs (Ivanova et al., 2002; Ramalho-Santos et al., 2002; Venezia et al., 2004).”
An extracellular matrix microarray for probing cellular differentiation (2005, background): “In vitro , undifferentiated mouse ES cells express integrins α6, β1, β4, β5, laminin receptor 1 and dystroglyca”
Stem cell origin of cancer and differentiation therapy. (2004, background): “Long-term hematopoietic stem cells show up-regulation of the frizzled Wnt receptor [36].”
Pluripotency: Toward a gold standard for human ES and iPS cells (2009, background): “In fact, analysis of three independent transcriptional profiling studies, each of which identified 200–300 genes associated with the pluripotent state, revealed only one gene in common (integrin alpha-6) (Ivanova et al., 2002; Ramalho-Santos et al., 2002; Fortunel et al., 2003).”
Socializing with the neighbors: stem cells and their niche. (2004, background): “Such a mechanismLRCs have been compared against specific progeny would explain why nonstem niche residents differ ac-(Ivanova et al., 2002; Stappenbeck et al., 2003; Tumbar cording to tissue type, and how they are neverthelesset al., 2004).”
Module map of stem cell genes guides creation of epithelial cancer stem cells. (2008, background): “Several studies have attempted to define a core transcriptional program of ''stemness,'' but the results have been controversial (Fortunel et al., 2003; Ivanova et al., 2002; Ramalho-Santos et al., 2002).”
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. (2005, neutral): “Under the presumption that self-renewal and differentiation are governed by a shared molecular mechanism, other authors have found similar gene expression patterns in various types of stem cells [60–63].”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “Approximately 200 protein-coding genes characterize this stem cell state (Ivanova et al. 2002; Ramalho-Santos et al. 2002) and many have established functions in maintenance of pluripotency (Ivanova et al.”