An extracellular matrix microarray for probing cellular differentiation
By Christopher J. Flaim, Shu Chien, Sangeeta N. Bhatia. Nature Methods, 2005
801 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/94d77c61daf47f79b08c2e4257e06b719ac9f018
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In Biomedical Engineering
- K. Anseth
- A. Mikos
- G. Vunjak‐Novakovic
- G. Reilly
- A. Atala
- Molly M. Stevens
- C. V. van Blitterswijk
- Matthias Wessling
In Molecular Biology
Citations in the corpus
- Engineering Complex Tissues (2006, positive): “Given that even subtle changes in ECM composition can have a dramatic effect on cellular differentiation, 280,285 it is reasonable to assume that a multitude of possibilities exist and we have merely scratched the surface.”
- An algorithm-based topographical biomaterials library to instruct cell fate (2011, background): “Hence, in recent years, there has been a shift from the rational design of biomaterials to combinatorial screening approaches used typically in the pharmaceutical industry for drug discovery, which we and others refer to as materiomics (17, 18).”
- Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, neutral): “experiment [92].”
- Small molecule functional groups for the controlled differentiation of human mesenchymal stem cells encapsulated in poly(ethylene glycol) hydrogels (2008, background): “Comprehensive studies have also demonstrated that surface function of two-dimensional (2D) materials has a role in differentiation of embryonic stem cells down the hepatocyte lineage based on ECM protein presentatio”
- Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “However, the sum of these cues is not always equal to its parts; cues of a similar type, such as the presentation of multiple ECM ligands, have been shown to have opposite effects on differentiation compared to their influence as individual cues or ligands (Flaim et al., 2005).”
- Complexity in biomaterials for tissue engineering. (2009, background): “This provides a way of identifying polymers that support desired responses from specified cell types, for example those that promote differentiation of human embryonic stem cell”