ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
By Wenxian Sun, Yang Li, Luoying Chen, Huihui Chen, Fuping You, Xiaoping Zhou, Yi Zhou, Z. Zhai, Danying Chen, Zhengfan Jiang. Proceedings of the National Academy of Sciences of the United States of America, 2009
856 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bd23c66a1c5f89904a4688c454a90a2705010a84
How researchers see this paper
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In Immunology
- Zhijian J. Chen
- Shizuo Akira
- O. Takeuchi
- Katherine A. Fitzgerald
- A. Bowie
- Tuo Li
- Taro Kawai
- S. Paludan
In Molecular Biology
- Zhijian J. Chen
- Shizuo Akira
- O. Takeuchi
- Katherine A. Fitzgerald
- Tuo Li
- A. Bowie
- S. Paludan
- Douglas R. Green
Citations in the corpus
- Immune sensing of DNA (2013, neutral): “(Ishikawa and Barber, 2008; Zhong et al., 2008; Jin et al., 2008; Sun et al., 2009).”
- The innate immune DNA sensor cGAS produces a non-canonical cyclic-di-nucleotide that activates human STING (2013, background): “An endoplasmic-reticulum-resident host protein called stimulator of IFN genes (STING; also called TMEM173, MITA, ERIS, and MPYS) was shown to be required for IFN response to cytosolic dsDNA (Ishikawa and Barber, 2008; Ishikawa et al., 2009; Sun et al., 2009; Zhong et al., 2008).”
- Pattern recognition receptors and inflammation. (2010, background): “Expression cloning of a gene inducing IFN-b promoter activation identified STING (also known as MITA, ERIS, or TMEM173), a transmembrane protein expressed in the ER (Ishikawa and Barber, 2008; Sun et al., 2009; Zhong et al., 2008).”
- Cyclic GMP-AMP Synthase is Activated by Double-stranded DNA-Induced Oligomerization (2013, background): “The endoplasmic reticulum (ER) membrane-localized adaptor protein STING is essential for the responses to cytosolic DNA (Barber, 2011b; Ishikawa and Barber, 2008; Ishikawa et al., 2009; Sun et al., 2009; Zhong et al., 2009).”