An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps.

By K. Beiter, F. Wartha, B. Albiger, S. Normark, Arturo Zychlinsky, B. Henriques‐Normark. Current Biology, 2006

616 citations recorded by the source corpus.

Subfields: Immunology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/1f0adcee4e15710e0f52e7f9cd19efbfe710e470

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Arturo Zychlinsky
2. P. Kubes
3. V. Brinkmann
4. V. Papayannopoulos
5. K. Martinod
6. D. Wagner
7. B. Yipp
8. Kathleen D. Metzler

In Public Health, Environmental and Occupational Health

1. V. Papayannopoulos
2. Arturo Zychlinsky
3. Kathleen D. Metzler

Citations in the corpus

• Neutrophil extracellular traps (NETs): Double-edged swords of innate immunity (2012, background): “degrade extracellular traps and may free the bacterium from NET chromatin (29).”
• Neutrophil extracellular traps: Is immunity the second function of chromatin? (2012, background): “, 2010) encode endonucleases that liber­ ate them from NETs, permitting the invasion of deeper organs (Beiter et al., 2006).”
• Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis (2011, neutral): “36,38 To test the functional significance of NETs in influenza, we performed endothelial injury and bactericidal activity studies.”
• Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010, background): “Notably, microbes have evolved virulence factors to degrade NETs (Beiter et al., 2006; Buchanan et al., 2006; Walker et al., 2007; Lauth et al., 2009).”
• Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans (2009, background): “Indeed, the importance of NETs in reducing dissemination seems likely to be similar to that observed in streptococcal pneumonia [10].”
• NETosis: how vital is it? (2013, background): “For S pneumoniae, endonucleases are inducible and allow bacteria to escape NET trapping resulting in dissemination from the lung into the blood.(62) In addition, encapsulation of pneumococcus provides resistance to NET trapping, potentially via electrochemical repulsion.”
• Novel cell death program leads to neutrophil extracellular traps (2007, positive): “Furthermore, the importance of NETs in host defense was recently demonstrated in models for necrotizing fasciitis (Buchanan et al., 2006) and pneumonia (Beiter et al., 2006).”
• The Multifaceted Functions of Neutrophils (2013, background): “Indeed, some staphylococcal and streptococcal strains express nucleases that degrade NETs to free the bacterium from the chromatin meshwork (126).”
• Thrombosis: tangled up in NETs. (2014, background): “23,33,34 Venous injury There may be a difference between arterial and venous responses to injury with respect to NETs.”
• Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “StreptococcalDNases render the bacteria resistant to NET-mediated killing [67–69].”
• Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. (2012, background): “…roles of NETs in host defense, NETs have been observed within tissues such as the skin and lungs, where they contribute to the containment of acute bacterial infections in animal models of cellulitis, necrotizing faciitis, and pneumonia (Beiter et al., 2006; Buchanan et al., 2006; Li et al., 2010).”
• Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis (2011, background): “In humans, NETs have been visualized in physiologic host responses to infections (44, 50) and have been implicated in the pathology of anti-neutrophil cytoplasmic Ab-induced vasculitis (51).”