T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

By A. Lighvani, D. M. Frucht, Dragana Jankovic, H. Yamane, J. Aliberti, B. Hissong, B. Nguyen, M. Gadina, A. Sher, W. E. Paul and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2001

763 citations recorded by the source corpus.

Subfields: Immunology, Parasitology

View Paper: https://www.semanticscholar.org/paper/1ec41ee3a95071be526ebcf51ab3348ce54287e5

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In Immunology

1. K. Murphy
2. G. Trinchieri
3. Sylvia M. Lee
4. K. Margolin

Citations in the corpus

• CD4+T Cells: Differentiation and Functions (2012, background): “However, STAT4 and T-bet do not function in a linear way in the differentiation of Th1 cell, with each having their unique signaling pathway.”
• Cytokines in Cancer Immunotherapy (2011, background): “IFN- is secreted by NK cells, NKT cells, Th1 CD4+ T-cells, CD8+ T cells, antigen presenting cells (APCs) and B-cells [55,56].”
• T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells (2002, background): “Indeed, it has been suggested that T-bet is regulated by IFN-γ signaling through STAT”
• Differentiation of Effector CD4 T Cell Populations (2010, neutral): “For Th1 differentiation, it was first shown that IL-12 (7) played a central role and only somewhat later was it appreciated that IFN-γ also played an important role in the induction of Th1 cells (39), of which IFN-γ is a signature cytokine.”
• Regulation of IFN-γ Production by B Effector 1 Cells: Essential Roles for T-bet and the IFN-γ Receptor1 (2005, background): “STAT1 up-regulates the expression of the transcription factor T-bet (24, 25), a recently described member of the T-box family of transcription factors (26).”
• Interleukin-12 and the regulation of innate resistance and adaptive immunity (2003, background): “So, in T cells that are becoming polarized, expression of T-bet is induced either stochastically or by instructive stimuli other than IL-12 — including probably other cytokines, such as IFN-&alpha”