The two NF-κB activation pathways and their role in innate and adaptive immunity

By G. Bonizzi, M. Karin. 2004

2,441 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1de0f9f13baf2224da00a3d555e4e8c03f93d7fa

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Citations in the corpus

• Innate immune recognition of viral infection (2006, background): “In contrast, NF-κB and ATF2–c-Jun are activated in response to various stimuli to regulate the expression of genes relevant to inflammatio”
• Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. (2008, background): “…and other inflammatory and immune regulators involves the activation of IKK by upstream mediators such as RIP2 and Tak1, followed by phosphorylation and degradation of I B in association with phosphorylation of GENES & DEVELOPMENT 1495 RelA/p65 (Bonizzi and Karin 2004; Hayden and Ghosh 2004).”
• NF-κB: linking inflammation and immunity to cancer development and progression (2005, background): “There are two distinct NF-κB-activation pathways: the classical pathway and the alternative pathwa”
• Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “TNF-α, is a proinflammatory cytokine generally produced by macrophages in response to pro-inflammatory signals [ 59 , 60].”
• NF-κB and the immune response (2006, background): “…et al., 1996; Shinkura et al., 1999) and share several phenotypic similarities with lymphotoxin and IKKa single knockout animals (Mebius, 2003; Bonizzi and Karin, 2004). p52/RelB, which is activated downstream of NIK and IKKa, is thought to be the primary transcriptional mediator of several…”
• TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. (2005, background): “In recent years, two NF- B activation pathways have been recognized that play distinct roles in the regulation of immune responses in mammals (Bonizzi and Karin 2004; Hayden and Ghosh 2004).”