Repression of p15INK4b expression by Myc through association with Miz-1

By P. Staller, Karen Peukert, A. Kiermaier, J. Seoane, J. Lukas, H. Karsunky, T. Möröy, J. Bartek, J. Massagué, F. Hänel and 1 more. Nature Cell Biology, 2001

627 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/1dcab253d1e8c7ac8bfcec09c98c4ba3cd216a97

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Citations in the corpus

Transcriptional regulation and transformation by Myc proteins (2005, background): “One example of such a 'tethering factor' is Miz1, which can recruit Myc and Max to core promoter sequences that lack a CACGTG sequenc”
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer (2003, background): “cgi?l=9063">MIZ1 to the proximal region of the CDKN2B and CDKN1A promoters, causing inhibition of transcriptio”
Myc's broad reach. (2008, background): “, cyclin-dependent kinase inhibitors [CDKIs]) (Staller et al. 2001; Herold et al. 2002; Knoepfler et al. 2002; Obaya et al. 2002), inhibit signal transduction pathways (Berwanger et al.”
TGFβ in Cancer (2008, background): “Additional coordination is provided by the transcription factor Miz-1, which in proliferating cells recruits c-Myc as a repressor to the transcriptional start regions of the p15INK4b and p21CIP1 promoters (Seoane et al., 2002; Staller et al., 2001) (Figure 5A).”
Smad transcription factors. (2005, background): “4C). c-Myc, in complex with Myc-interacting zincfinger protein-1 (Miz1), binds to a proximal promoter region of p15Ink4b and p21Cip1, inhibiting the expression of these genes (Seoane et al. 2001; Staller et al. 2001).”
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage (2002, background): “We recently elucidated the mechanism of Myc inhibition of p15 Ink4b expressio”
MYC, metabolism, cell growth, and tumorigenesis. (2013, background): “These findings, however, do not account for the groups of genes that are repressed by MYC (Seoane et al. 2001; Staller et al. 2001).”
Widespread microRNA repression by Myc contributes to tumorigenesis (2008, background): “For example, Myc can bind to and inhibit the activity of the transcription factor Myc-interacting zinc finger protein 1 (Miz1), thereby preventing Miz1 from activating transcription of the CDKN1A (also known as p21 WAF1/CIP1 ) and CDKN2B (p15 INK4b ) cell cycle–inhibitory gene”
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, background): “…role for c-Myc in intestinal stem cell driven maintenance of mucosa is further suggested by expression profiling of microdissected early progenitor populations from intestinal crypts in which a number of genes either controlling or controlled by c-Myc have been identified (Stappenbeck et al. 2003).”
MYC as a regulator of ribosome biogenesis and protein synthesis (2010, background): “Second, MYC–MAX complexes can bind to a core promoter element — the initiator (Inr) — through the transcription factor MIZ1 (also known as PIAS2”
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all (2006, background): “Activation by TGFβ is attributed to downregulation of MYC and the recruitment of the activating factors SMAD, MIZ1 and SP1 to the INK4b promote”
Myc and cell cycle control. (2015, background): “CDKN2B (p15) Repressed Rat [223] and mouse fibroblasts [104]”