Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood.

By C. Heim, D. Newport, S. Heit, Y. Graham, M. Wilcox, R. Bonsall, A. Miller, C. Nemeroff. Journal of the American Medical Association (JAMA), 2000

1,886 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Clinical Psychology

View Paper: https://www.semanticscholar.org/paper/1d939ca6831976d2149d4ce345b50965e264ee47

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Citations in the corpus

Sex differences in HPA axis responses to stress: a review. (2005, background): “A dysfunctional HPA axis is associated with manifestations of psychosomatic and psychiatric disorders (for reviews, see Chrousos and Gold, 1992; Heim et al., 2000a,b; Holsboer, 1989; Raison and Miller, 2003; Stratakis and Chrousos, 1995; Tsigos and Chrousos, 1994; Tsigos and Chrousos, 2002; Young,…”
Victimization and Substance Abuse among Women: Contributing Factors, Interventions, and Implications (2002, background): “However, Heim et al. (2000) suggested that childhood abuse is associated with persistent sensitization or hyperactivity of the HPA axis and the autonomic stress response, which is an abnormal biological state that can cause changes in brain structures and, in turn, may contribute to greater…”
Deep brain stimulation for treatment-resistant depression. (2005, positive): “While mechanisms driving this “system dysfunction” are not yet characterized, they are likely to be multifactorial, with genetic vulnerability, developmental insults, and environmental stressors all considered important and synergistic contributors (Caspi et al., 2003; Heim et al., 2000; Kendler et ”
Childhood abuse as a risk factor for psychotic experiences (2003, background): “Specifically, when exposure to stressors persists and heightened stressinduced glucocorticoid release is chronic, there can be permanent changes in the hypothalamic–pituitary–adrenal (HPA) axis (53, 54).”
Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge. (2009, background): “…significant interactional effects of psychiatric symptoms in adult life and childhood trauma on HPA axis responses to psychological stress and pharmacological stimulation assessed during adulthood (Heim et al., 2000, 2008), though salivary cortisol responses have not been reported in these studies.”
Positive health: connecting well-being with biology. (2004, background): “…linked with neuroendocrine factors, although most inquiry has focused on the negative, such as elevated levels of cortisol , adrenaline or noradrenaline among caregivers (Cacioppo 1994; Uchino et al. 1996; Cacioppo et al. 1998) and those exposed to early childhood abuse (Heim et al. 2000).”
Child maltreatment and the developing HPA axis. (2006, result): “In contrast to the TSST psychological stressor, CRH challenge yielded a blunted ACTH response in depressed maltreated women compared to the nonmaltreated depressed group (Heim et al., 2000; Heim and Nemeroff, 2001).”
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. (2001, background): “We found that abused women with or without current depression exhibit markedly increased plasma ACTH responses to psychosocial laboratory stress compared with control subjects and depressed women without early life stress (Heim et al 2000).”
Effects of stress throughout the lifespan on the brain, behaviour and cognition (2009, background): “Studies of adults who suffered childhood abuse also reveal hyper-reactivity of the HPA axis in abused, depressed individual”
Adverse childhood experiences, allostasis, allostatic load, and age-related disease. (2012, methodology): “For example, adults with a history of childhood maltreatment and current depression showed greater ACTH and cortisol response to the Trier Social Stress Test compared to non-maltreated and non-depressed controls [130].”
“The Biological Effects of Childhood Trauma” (2014, neutral): “Additionally, no cortisol response differences [39, 50, 51], blunted cortisol responses[52], and increased cortisol concentration responses [53, 54] have been reported in maltreated children and adults with histories of childhood maltreatment under psychological and pharmacological challenges.”