Adult bone marrow stromal cells differentiate into neural cells in vitro.

By Juan Sanchez-Ramos, Shijie Song, F. Cardozo‐Pelaez, C. Hazzi, T. Stedeford, A. Willing, T. Freeman, S. Saporta, W. Janssen, N. Patel and 2 more. Experimental Neurology, 2000

1,650 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/1caccd3a64cc5e4873ec1515fc3cc828dd5e8deb

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In Cancer Research

1. A. Caplan

In Developmental Neuroscience

1. Helen M. Blau
2. T. Brazelton
3. A. Caplan
4. J. Weimann

In Genetics

1. A. Caplan
2. Frank Barry
3. Helen M. Blau
4. T. Brazelton
5. J. Weimann
6. D. Prockop

Citations in the corpus

• The In Vitro Migration Capacity of Human Bone Marrow Mesenchymal Stem Cells: Comparison of Chemokine and Growth Factor Chemotactic Activities (2007, background): “MSCs also generate cells that do not belong to the hematopoietic microenvironment that are mesodermal in origin, such as chondrocytes [3] and cardiac or skeletal muscle cells [5, 6], but may be also neuro-ectodermal (neurons, astrocytes, oligodendrocytes) [7, 8] or endodermal (hepatocytes) [9, 10].”
• Mesenchymal stem cells as trophic mediators (2006, background): “Because published reports assert that MSCs are capable of differentiating into neural elements [Sanchez-Ramos et al., 2000; Woodbury et al., 2000], it could be argued that if MSCs were introduced into an ischemic sector of brain, newly differentiated neural elements from the MSCs could play a role…”
• Adult bone marrow is a rich source of human mesenchymal ‘stem’ cells but umbilical cord and mobilized adult blood are not (2003, background): “Their reported ability to differentiate down multiple lineages includes osteogenic (Jaiswal et al, 1997), adipogenic (Pittenger et al, 1999), chondrogenic (Yoo et al, 1998) and neural differentiation (Sanchez-Ramos et al, 2000).”
• Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. (2002, background): “Two recent reports have shown that human MSCs could differentiate in vitro into neurons (49, 57) and astrocytes (49).”
• Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. (2002, background): “BM contains cells that can contribute to a number of mesodermal [1–7], endodermal [8–11], neuroectodermal [12,13,31,32], and skin [11] structures.”
• Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis (2010, background): “Mesenchymal stem cells cultivated under different culture manipulations (chemical induction or use of growth factors) can give rise to neural-like, glial-like, and astrocyticlike cells in vitro.(15-19) In rats with an induced focal demyelinated lesion of the spinal cord, intravenous or intracerebral”
• Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow (2003, background): “…adipose and other tissues have been demonstrated to have the potential to differentiate into cells with characteristics of neurons, oligodendrocytes, and astrocytes [Kopen et al., 1999; Brazelton et al., 2000; Sanchez-Ramos et al., 2000; Woodbury et al., 2000; Deng et al., 2001; Toma et al., 2001].”
• A Long‐Term Follow‐Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke (2010, background): “MSCs are multipotent and can transdifferentiate into neural cells [5] [6].”
• Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. (2007, background): “The transdifferentiation can be induced by neuronal induction medium [14-17] and/ or cell contact with neurons [18].”