Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage.

By Evelyn K. F. Yim, S. Pang, K. Leong. Experimental Cell Research, 2007

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Extracellular matrix dynamics in development and regenerative medicine (2008, background): “Studies using another culture system have demonstrated that nanotopography strongly influences stem cell differentiation; seeding cells on a nanograting that has a diameter one order of magnitude less than the width of the cell more effectively promotes neuronal differentiation of human MSCs than do”
The regulation of tendon stem cell differentiation by the alignment of nanofibers. (2010, background): “The aligned nanofibers are suitable for ligament cell proliferation and orientation under a mechanical stimulus [39], and scaffolds with an aligned nanotopography are effective in enhancing axon extrusion from neuronal stem cells [24,40].”
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells (2009, background): “nanotopography alone can upregulate the neuronal markers of human mesenchymal stem cells (hMSCs) [5].”
Nanotopography-guided tissue engineering and regenerative medicine (2012, background): “[240] that no significant neuronal differentiation was reported on 10 μm patterns as compared to flat controls, micropatterns over 10 μmmay not be effective for the neuronal differentiation.”