Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.

By H.Steven Zhang, M. Gavin, A. Dahiya, A. Postigo, Duanduan Ma, Robin X. Luo, J. Harbour, Douglas C. Dean. Cell, 2000

709 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1c19c33aa6f880528d8b5b3f9afd2bbf5a78755e

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Citations in the corpus

Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle (2006, methodology): “Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle e125”
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “At the restriction point this inhibition is removed by hyperphosphorylation of RB by cyclinE-CDK2 which leads to release of E2Fs, thereby promoting transcription of S phase genes and hence progression of the cell cycle (Zhang et al., 2000).”
RB and cell cycle progression (2006, background): “…repression is enhanced by HDAC1 in transient transfection experiments, and to confirm this association between pRb and HDAC, it has been shown that inhibition of HDAC activity with trichostatin A interferes with pRBmediated repression at a subset of E2F-regulated promoters (Zhang et al., 2000).”
Minireview: Cyclin D1: normal and abnormal functions. (2004, background): “The human ortholog of hSWI/SNF, BRG1, also forms a transcriptional repressor complex with pRb that is required for pRb-mediated growth suppression (47).”
The Pezcoller lecture: cancer cell cycles revisited. (2000, background): “11) and recruiting repressors such as histone deacetylases (12–14) and chromosomal remodeling SWI/SNF complexes (15) to E2F-responsive promoters on DNA.”
The SWI/SNF complex and cancer (2009, background): “Constitutively active RB does not induce G1 arrest in cells that lack BRG1 and BRM expression (Strobeck et al., 2000, 2001, 2002; Zhang et al., 2000; Reisman et al., 2002).”
Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis (2001, background): “A second possibility could relate to the recent studies of Dean and colleagues, which provide evidence for two forms of E2F/Rb-mediated transcription repression (25).”
Pocket proteins and cell cycle control (2005, background): “Pocket proteins may also repress transcription through HDAC-independent mechanisms, both in Drosophila (Taylor-Harding et al., 2004) and in mammalian cells (Strobeck et al., 2000; Zhang et al., 2000), as discussed for cyclin A below.”
The Rb/E2F pathway: expanding roles and emerging paradigms. (2000, methodology): “Although BRG1 contains an LXCXE, it does not require this sequence to bind Rb, which allows Rb to recruit BRG1 and HDAC1 into a single complex (Zhang et al. 2000).”