Pocket proteins and cell cycle control

By D. Cobrinik. Oncogene, 2005

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MicroRNA control in the immune system: basic principles. (2009, background): “P21, Rbl2, E2F1, E2F2, and E2F3 regulate cell cycle progression at the G1 to S transition (Balomenos et al., 2000; Cobrinik, 2005; Field et al., 1996; Massague, 2004; Murga et al., 2001; Santiago-Raber et al., 2001; Yamasaki et al., 1996; Zhu et al., 2001).”
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “More specifically, CDK4/6- CYCLIN D phosphorylates RB at Ser807 and Ser811, causing the release of E2F, and free E2F helps transcribe key genes for the transition of G1/S, including CYCLIN E and CYCLIN A [446,447].”
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition (2007, background): “Among the E2F-regulated genes are Cyclin E, Cyclin A2 and Emi1, which are key effectors of the G1/S transition in normal cells (Hsu et al., 2002; Cobrinik, 2005).”
RB and cell cycle progression (2006, background): “Pocket proteins may also regulate the earlier transition from G0 to G1 (Cobrinik, 2005).”