Why New Neurons? Possible Functions for Adult Hippocampal Neurogenesis

By Gerd Kempermann. 2002

500 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

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Citations in the corpus

Generalization Through the Recurrent Interaction of Episodic Memories (2012, background): “…evidence points to a role in enhancing the orthogonalization capabilities of the DG, given that its disruption produces a specific impairment in paradigms where pattern separation demands are high (Becker, 2005; Clelland et al., 2009; Deng et al., 2010; Kempermann, 2002; Nakashiba et al., 2012).”
Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment (2002, background): “Using correlational data, we have speculated about the potential functional relevance of adult hippocampal neurogenesis.(57) To date, no proof of the hypothesis that new neurons are necessary for hippocampal function has been discovered, although the link has been inferred and it has been shown that”
Learning Enhances the Survival of New Neurons beyond the Time when the Hippocampus Is Required for Memory (2004, background): “F, 4).”
Radiation-Induced Cognitive Impairments are Associated with Changes in Indicators of Hippocampal Neurogenesis (2004, background): “Therefore, it has been suggested that even a few new hippocampal neurons, if strategically localized within a network, could significantly increase the complexity and thereby the processing capacity of that network (56).”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “These models represent perhaps the best current evidence for a commonly proposed function of adult neurogenesis: that, rather than (or as well as) participating in the storage of new information, it endows a network with the ability to adapt to future changes in inpu”
Simulated Apoptosis/Neurogenesis Regulates Learning and Memory Capabilities of Adaptive Neural Networks (2004, background): “Our simulation results demonstrate a fundamental neural systems mechanism by which regulation of rates of neuronal apoptosis and/or neurogenesis within individuals might serve to gauge associated informatic costs and benefits according to the degree of new information demands (Kempermann, 2002).”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “However, the functional significance of adult neurogenesis remains unclear (Kempermann, 2002; Schinder and Gage, 2004).”
Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “It has been hypothesized that, in the adult hippocampus, neurogenesis is involved in learning and memory (42).”
A computational principle for hippocampal learning and neurogenesis (2005, background): “life, Kempermann (2002) has suggested that the gradual addition of new neurons into the existing network of the DG could allow the hippocampus to deal with novelty and the concomitant evolution of cortical representations.”
The stress system in the human brain in depression and neurodegeneration. (2005, background): “As ''strategic gatekeepers'' (Kempermann, 2002; Kempermann and Kronenberg, 1999), stress effects on DG neurons are likely to be reflected by changes in, e.g., synaptic transmission at the CA3 synapses or dendrites.”
Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli (2003, background): “The controlled addition of new neurons to the adult hippocampus has received widespread scientific interest because of its many implications for our understanding of hippocampal function and pathology (D’Sa and Duman, 2002; Gould and Gross, 2002; Kempermann, 2002; Parent and Lowenstein, 2002).”
Adolescent cortical development: a critical period of vulnerability for addiction. (2007, background): “Generating and integrating new neurons into preexisting neuronal circuits is believed to enable the hippocampus to adapt to novel and more complex situations (Kempermann, 2002).”