Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines.

By A. Vgontzas, E. Zoumakis, E. Bixler, Hung-Mo Lin, H. Follett, A. Kales, George P. Chrousos. Journal of Clinical Endocrinology and Metabolism, 2004

1,030 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/1bb50319b1bd7159a55413fc566bfbf0a0897e8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Michael R. Irwin
2. Jan Born
3. Bruce S. McEwen

In Experimental and Cognitive Psychology

1. Michael R. Irwin
2. M. Haack
3. Luciana Besedovsky
4. T. Lange
5. Jan Born
6. Bruce S. McEwen

Citations in the corpus

• Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “Even mild reductions in sleep quantity can increase inflammation levels (Vgontzas et al, 2004), suggesting that chronic problems with sleep, which is characteristic of PTSD and GAD, could contribute to a pro-inflammatory state.”
• Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “Sleep deprivation results in increased circulating levels of IL-6, TNF-α, and Creactive protein when compared to periods of undisturbed sleep (Vgontzas et al., 1999, Meier-Ewert et al., 2004, Vgontzas et al., 2004).”
• Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective (2014, background): “…periods of sleep restriction (i.e., seven nights) induce increases in plasma concentrations of IL-6 in men and women, increases of TNF in men only (Vgontzas et al. 2004a), and increases in inflammatory transcripts of IL-1β, IL-6, and IL-17 (van Leeuwen et al. 2009), with evidence that such…”
• Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. (2006, background): “Proinflammatory cytokine levels are increased, along with performance in tests of psychomotor vigilance, and this has been reported to result from a modest sleep restriction to 6 hours per night [18].”
• Sleep and immune function (2011, background): “Interestingly, even a relatively mild restriction of sleep from 8 to 6 h for 8 days effectively heightened the level of proinflammatory cytokines [122].”
• Cardiovascular, Inflammatory and Metabolic Consequences of Sleep Deprivation (2009, background): “Interestingly, IL-6 and CRP have both been found to increase during acute total sleep deprivation (54,13) and also during sleep restricted to half the normal daily amount for 10 days (13,55) and in one study, even when sleep is reduced by 25% of the normal amount for 8 nights (56).”
• Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. (2006, background): “Given that monocyte production of proinflammatory cytokine contributes to increases in circulating levels,(20) we speculate that morning elevations in cellular proinflammatory cytokine expression might have consequences for subsequent daytime elevations.(13) Loss of sleep during only part of the nig”
• Protective and damaging effects of stress mediators: central role of the brain (2006, background): “Proinflammatory cytokine levels are increased, along with performance in tests of psychomotor vigilance, and this has been reported to result from a modest sleep restriction to 6 hours per night.(19) Reduced sleep duration was reported to be associated with increased body mass and obesity in the NHA”