Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

By Hamid Cheshmi. 2011

2,527 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1bb43e9a281a921eb6c061d4e6d6fe62600a0a3e

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Citations in the corpus

Exosomes as Drug Delivery Vehicles for Parkinson’s Disease Therapy (2015, background): “Regrettably, the blood brain barrier (BBB) severely limits transport of this large protein.”
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. (2010, background): “The release mechanisms may be complicated and may involve tumor-derived microvesicles/exosomes.(29,30) Microvesicles are 30 to 100 nm in diameter and are shed from many different cell types under both normal and pathologic conditions.”
Circulating Exosomal microRNAs as Biomarkers of Colon Cancer (2014, background): “Therefore, exosomal miRNAs in body fluids may be useful diagnostic biomarkers for the detection of cancer [10,15].”
Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs (2010, background): “It has been suggested that MVs, after internalization within target cells through surfaceexpressed ligands, may transfer not only proteins, bioactive lipids and mRNAs but also microRNAs (miRNAs) [2,11].”
Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. (2011, background): “Essentially, exosomes carry and protect fragile mRNA, miRNA and proteins within their core (23-25).”
Cellular Internalization of Exosomes Occurs Through Phagocytosis (2010, result): “Although previous reports indicated that exosomes could be taken up by several cell types (26,27), how exosomes interact with recipient cells and how exosomes are sorted after entry into these cells remain unclear (28–30).”
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, methodology): “It is of note that some exosomal miRNAs can be used to aid in clinical diagnosis ( Table 1 ) [29,30,54,62].”
Interaction and uptake of exosomes by ovarian cancer cells (2011, background): “Furthermore, the exosomes may transfer mRNA and miRNA [36].”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, unknown): “EVs have the potential to deliver combinatorial information to multiple cells in their tissue microenvironment and throughout the body (Baj-Krzyworzeka et al. 2006; Ratajczak et al. 2006; Skog et al. 2008).”
Manufacturing Exosomes: A Promising Therapeutic Platform. (2018, unknown): “On the one hand, EVs have been proposed as diagnostic biomarkers of disease in cancers as diverse as ovarian cancer [22,23], glioblastoma [19], melanoma [24] prostate cancer [25], and colon cancer [26], based on unique miRNA profiles and other cargo that is transmitted with pathological effect.”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “From the time of their initial description in EVs (Ratajczak et al. 2006, Skog et al. 2008, Valadi et al. 2007), we have known that mRNA were not randomly secreted in exosomes, because different sequences were either preferentially secreted or, conversely, retained inside the cells.”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “Indeed, inclusion of miRNAs in microvesicles, exosomes, apoptotic bodies, and complexes with proteins converts protection from RNase-dependent degradation (116, 244, 268).”
Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013, unknown): “The discovery that exosomes and microvesicles may mediate intercellular communication via the delivery of genetic materials from one cell to another served as an impetus for renewed interest in extracellular vesicles as potential cancer biomarkers [1, 112].”