A dynamic role for the mushroom bodies in promoting sleep in Drosophila

By Jena L. Pitman, Jermaine J. McGill, Kevin P. Keegan, R. Allada. 2006

338 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Genetics

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “…play a role in experiencedependent regulation of proboscis extension (Masek and Scott, 2010) and courtship (McBride et al., 1999) as well as regulation of sleep (Joiner et al., 2006; Pitman et al., 2006) and post-mating behaviors such as oviposition (Fleischmann et al., 2001; Azanchi et al., 2013).”
A neural circuit mechanism integrating motivational state with memory expression in Drosophila (2009, background): “Given the apparent role of the MB as a locomotor regulator (Huber, 1967; Martin et al., 1998; Pitman et al., 2006; Joiner et al., 2006), MB-MP neurons may also generally promote exploratory behavior.”
Neuronal assemblies of the Drosophila mushroom body (2008, background): “…and Strausfeld, 1999; Liu et al., 1999; McBride et al., 1999; Joiner and Griffith, 1999; Tang and Guo, 2001; Perez-Orive et al., 2002; Siwicki and Ladewski, 2003; Besson and Martin, 2005; Brembs and Wiener, 2006; Joiner et al., 2006; Pitman et al., 2006; Acevedo et al., 2007; Keleman et al., 2007).”
Propagation of homeostatic sleep signals by segregated synaptic microcircuits of the Drosophila mushroom body (2015, neutral): “While a mutation of the amnesiac gene, which is expressed in a pair of neurons innervating the MB lobes, was shown to impair homeostatic sleep rebound [39], rebound was not found to be strongly affected by very broad synaptic inactivation of the MB KCs that comprise the lobes [4].”
A map of olfactory representation in the Drosophila mushroom body. (2007, neutral): “The whole MBs (gray) are segmented from DiD-stained brains and used as internal references for brain warping.”
Short neuropeptide F is a sleep-promoting inhibitory modulator (2013, methodology): “We used multiple strategies to test the involvement of the MB because it is a previously identified sleep-promoting region (Joiner et al., 2006; Pitman et al., 2006) Addition of a MB-GAL80 transgene blocked the expression of dTRPA1 in the MB without affecting the sleep-promoting effect of sNPFGAL4:d”
PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. (2008, neutral): “All behavior was done on female flies unless explicitly indicated.”
Genetic manipulation of genes and cells in the nervous system of the fruit fly (2011, methodology): “UAS-Shibirets1 has been used to identify neurons involved in courtship, sleep, color vision, and taste discrimination (Kitamoto, 2002; Broughton et al., 2004; Pitman et al., 2006; Gao et al., 2008b; Masek and Scott, 2010).”
Sequential use of mushroom body neuron subsets during drosophila odor memory processing. (2007, neutral): “, 1999) and sleep (Joiner et al., 2006; Pitman et al., 2006).”
Are mushroom bodies cerebellum-like structures? (2011, background): “, 2007a), habit formation (Brembs, 2009), sleep (Joiner et al., 2006; Pitman et al., 2006), fixation behavior and attention (van Swinderen, 2005; Xi et al.”
A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster (2015, background): “While it has been shown previously that the Drosophila MB can promote sleep (Joiner et al., 2006; Pitman et al., 2006; Yi et al., 2013), a specific role for the α’/β’ lobes has not been reported.”