Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects.

By J. Shake, P. Gruber, W. Baumgartner, Guylaine Sénéchal, J. Meyers, John Redmond, M. Pittenger, B. Martin. Annals of Thoracic Surgery, 2002

939 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/1ada8c1880ca3e899d87a4be5d083e668add5d03

How researchers see this paper

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In Genetics

1. A. Caplan
2. Rocky S. Tuan
3. D. Prockop
4. Elizabeth Cho
5. Catherine M. Kolf

In Molecular Biology

1. A. Engler
2. Dennis E. Discher
3. A. Stolzing
4. S. Lim
5. A. Caplan
6. A. Scutt
7. K. Kangawa
8. Rocky S. Tuan

In Surgery

1. Rocky S. Tuan
2. A. Caplan
3. Elizabeth Cho
4. Catherine M. Kolf

Citations in the corpus

• Adult mesenchymal stem cells for tissue engineering versus regenerative medicine (2007, background): “Impressively, Mark Penn and his collaborators (Shake et al., 2002; Askari et al., 2003) have started to provide detailed molecular and cellular characterizations of the mechanisms governing the mobilization, attraction, and functioning of MSCs at heart infarct sites in rodents.”
• Aging of mesenchymal stem cells. (2006, background): “Recent evidence suggests that the process of tissue repair is driven by tissue-specific progenitor cells which are replenished by MSC from bone marrow by migration– differentiation (Shake et al., 2002), fusion (Kotton et al.”
• Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy (2005, methodology): “9 In addition, MSC implantation induces therapeutic angiogenesis in a rat model of hindlimb ischemia through vascular endothelial growth factor (VEGF) production by MSCs. 10,11 Myocardial blood flow abnormalities, even in the presence of angiographically normal coronary arteries, have been…”
• Multipotential differentiation of adipose tissue-derived stem cells. (2005, background): “transplantation, (2) high proliferation rates for ex vivo expansion and (3) multilineage differentiation”
• Mesenchymal stem cells as trophic mediators (2006, methodology): “At least a portion of the therapeutic improvement of MSC administration has been ascribed to attenuation of ventricular wall thinning [Shake et al., 2002] and increased angiogenesis [Min et al., 2002].”
• Adult mesenchymal stem cells and cell-based tissue engineering (2002, background): “Some groups have examined the treatment of myocardial infarction by application of autologous MSCs in the pig model, and these studies show engraftment, differentiation, and improved function in animals treated with autologous marrow MSCs [132].”