Aging of mesenchymal stem cells.

By Sebastian C. Sethe, A. Scutt, A. Stolzing. Ageing Research Reviews, 2006

639 citations recorded by the source corpus.

The role of adult mesenchymal stem cells (MSC) in tissue maintenance and regeneration has received significant attention of late. Questions arise to what extent these cells are either subject to, or causes of aging; whether age-related changes in these cells are due to intrinsic factors or induced by the somatic environment. This review collates and examines recent data in support of these different theories. By means of introduction, a brief overview is given of current MSC definitions and their basic role in tissue regeneration followed by a comparative analysis of gerontological studies involving MSC. Evidence for extrinsic aging and various aging markers relating to morphology, proliferation, signalling, senescence markers, telomeres and telomerase, and other indicators is discussed. We observe that while the literature might often appear to conflict, many apparent discrepancies are attributable to inconsistent methods of extracting and isolating MSC which in fact contains various subsets of adult stem cells, varying not only in their differentiation potential but also in their vulnerability to senescence--ranging from quasi-somatic lifespan to perennial vigour. Thus, mesenchymal stem cells emerge as both subject to and key mediators of organismal aging.

Subfields: Genetics, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/4bf7159f4a835621f3149d02acc23e303937aea9

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In Physiology

1. A. Stolzing
2. A. Scutt

Citations in the corpus

• The Mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (2015, neutral): “Nonetheless, mitochondria also relay information via several known retrograde signaling molecules, such as reactive oxygen species (ROS), Ca, and cytochrome C (Goodwin et al., 2009; Houtkooper et al., 2011; Sethe et al., 2006).”
• Age‐related intrinsic changes in human bone‐marrow‐derived mesenchymal stem cells and their differentiation to osteoblasts (2008, background): “A more recent review concluded that differences in isolation methods (whole marrow, low-density fraction, adherent stroma), sources (biopsies and necropsies), anatomical sites, colony assay protocols, and ambiguous terminology confound integration of the literature and resolution of apparently confl”
• From the laboratory bench to the patient's bedside: An update on clinical trials with mesenchymal stem cells (2007, background): “…forming unit (CFU) assay that identifies adherent spindle shaped cells that proliferate to form colonies and can be induced to differentiate into adipocytes, osteocytes, and chondrocytes (Prockop, 1997; Bianco and Gehron Robey, 2000; Beyer Nardi and da Silva Meirelles, 2006; Sethe et al., 2006).”
• Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. (2008, background): “Despite this, the majority of reports describe an overall decline in osteogenic potential with donor age regardless of species ( Sethe et al., 2006 ).”
• Biomimetic nanofibrous scaffolds for bone tissue engineering (2011, neutral): “and can undergo 40 population doublings in culture [61], although their proliferation rate is slow [62].”