Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

By A. Caplan. Journal of Cellular Physiology, 2007

2,023 citations recorded by the source corpus.

Subfields: Biomaterials, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/a3b36a4c9b2d5728740d42046b5ce5d6f7665032

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Citations in the corpus

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine (2017, background): “Nevertheless, it is also remarkable that MSCs inhibit proinflammatory cytokines, such as interferon (IFN)-γ and tumor necrosis factor α (TNFα), while increasing antiinflammatory IL10 release [84,85].”
All MSCs are pericytes? (2008, background): “…emphasized by using cell sorting for pericytes (CD146+, CD34 , CD45 , CD56 ) and subsequent in vitro expansion to document that the sorted cells or clones are multipotent for osteogenic, chondrogenic, adipogenic, and myogenic lineages in vitro, which are hallmarks of MSC identity (Caplan, 2007).”
Comparative Analysis of Human Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue, and Umbilical Cord Blood as Sources of Cell Therapy (2013, positive): “Mesenchymal stem cells (MSCs) possess self-renewal and multi-lineage differentiation potentials, and are thus an attractive source of stem cells for tissue engineering [1,2].”
The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration (2011, background): “, cartilage, bone, ligaments, muscle, fat, dermal, and other connective tissue), and can therefore be used to engineer mesenchymal derived tissue [126].”
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6 (2009, methodology): “Currently MSCs are being employed in clin- ical trials in heart disease, Crohn’s disease, cartilage repair, stroke, spinal cord injury, and several other diseases (Prockop and Olson, 2007; Caplan, 2007; Giordano et al., 2007).”
Mesenchymal Stem Cell-Based Tissue Regeneration is Governed by Recipient T Lymphocyte via IFN-γ and TNF-α (2011, background): “To date, a variety of preclinical and clinical studies have shown that exogenously added BMMSCs can give rise to the generation of new bone and bone-associated tissues to replace damaged and diseased tissues by assisting the regenerative capacities of endogenous cells in the defec”
The elusive nature and function of mesenchymal stem cells (2011, neutral): “The unequivocal identification of MSCs in vivo has been hindered by their extremely low frequency in tissue”
Challenges in the Treatment of Chronic Wounds (2015, background): “Furthermore, the MSCs in these tissues do not suffer from the age-related effects nor decreased cell counts as found in MSCs harvested from adult patients with comorbid diseases.(279,293,295) Placental-derived MSCs show minimal differences from those obtained from different sites, and yet retain all”
Repair and tissue engineering techniques for articular cartilage (2014, positive): “60 By creating a regenerative environment with the release of chemotactic factors, 61 bone marrow MSCs might also drive endogenous stem cells to enter the cartilage defect and aid in the regeneration of damaged tissue.”