Mutations affecting segment number and polarity in Drosophila

By Christiane Nüsslein-Volhard, E. Wieschaus. 1980

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Citations in the corpus

Iterative random forests to discover predictive and stable high-order interactions (2017, neutral): “For instance, interactions among gap proteins Giant (Gt), Krüppel (Kr), and Hunchback (Hb), some of the most well-characterized interactions in the early Drosophila embryo (32), are all highly stable [sta(Gt-Kr)= 1.”
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning (2009, methodology): “The full set of positive and negative counts was fit with a beta-binomial model (1).”
The art and design of genetic screens: Drosophila melanogaster (2002, unknown): “This all changed when Christiane Nüsslein-Volhard and Eric Wieschaus published their Nobel-prize-winning Nature paper on mutations that affect the patterning of the embryo 10 (FIG.”
The Primary Cilium as a Complex Signaling Center (2009, background): “Hedgehog (Hh) is a secreted protein regulating a vast number of developmental processes in both vertebrates and invertebrates [57,58].”
Hedgehog signalling in cancer formation and maintenance (2003, background): “HH signalling pathway components The Hh signalling pathway was first identified in a large Drosophila screen for genes that were required for patterning of the early embry”
CBP/p300 in cell growth, transformation, and development. (2000, background): “It is possible that this discrepancy relates to differences between the Xenopus and Drosophila systems.”
Dynamic reprogramming of chromatin accessibility during Drosophila embryo development (2011, background): “This morphological patterning is directed by a temporally ordered regulatory cascade [4-8].”
Wnt/β-catenin signaling and disease. (2012, unknown): “The fly Wingless (wg) gene, which controls segment polarity during larval development (Nüsslein-Volhard and Wieschaus, 1980), was later shown to be a homolog of Wnt1 (Rijsewijk et al.”
Spatio-temporal dynamics of a reaction-diffusion system for a predator–prey model with hyperbolic mortality (2014, background): “The original idea of generating patterns from diffusion was proposed by Turing [34] more than 60 years ago, and since then it has been an active area [18,20,25,28,30], and numerous works have been done numerically [24,28] and theoretically [8,26,27].”
Hedgehog signaling in animal development: paradigms and principles. (2001, background): “As with many of the advances in our understanding of the genetic regulation of animal development, hedgehog (hh) genes owe their discovery to the pioneering work of Nüsslein-Volhard and Wieschaus (1980).”
Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing? (2019, background): “While mutant lines (see Glossary) in many species were initially established through forward genetic screens (Brenner, 1974; Nüsslein-volhard and Wieschaus, 1980; Haffter et al., 1996; Driever et al., 1996; Nolan et al., 2000; de Angelis et al., 2000), the recent development of zinc-finger nucleases”
Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions (2009, background): “Only 40 to 50 sequence-specific regulators provide the spatial and temporal patterning information to the network, making it particularly tractable for system-wide analyses [13-15].”