Dynasore, a cell-permeable inhibitor of dynamin.

By E. Macia, M. Ehrlich, Ramiro H. Massol, Emmanuel Boucrot, C. Brunner, T. Kirchhausen. Developmental Cell, 2006

2,051 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1aa166dad19e678bed4cc666a14bf3c8811450a5

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Citations in the corpus

Pathways of clathrin-independent endocytosis (2007, neutral): “However, other methods are needed to assess the effects of the various dynamin isoforms on CI internalization, such as siRNA-mediated depletion and the use of more specific inhibitors of dynami”
The effect of particle design on cellular internalization pathways (2008, background): “All inhibitors were obtained from Sigma-Aldrich except for Dynasore, which was obtained from ChemBridge.”
HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes (2009, neutral): “The dynamin inhibitor, dynasore ( Macia et al., 2006 ), and Cdc42 inhibitor, secramine A (Pelish et al., 2006) were synthesized by H. Pelish and kindly provided by Dr. T. Kirchhausen (Harvard Medical School).”
Robust single particle tracking in live cell time-lapse sequences (2008, background): “Treatment of cells with dynasore, a small-molecule inhibitor of dynami”
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β (2008, background): “and a highly specific inhibitor of dynamin called 'dynasore”
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication (2013, positive): “To determine whether neurons internalize oligodendroglial exosomes by endocytosis, we pretreated neurons with Dynasore and Pitstop-2 inhibiting dynamin and clathrin-dependent endocytosis, respectively [43,44].”
A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis (2011, neutral): “previous observations [32] (Figure 2B and 2D).”
Neutrophil Elastase-Mediated Degradation of IRS-1 Accelerates Lung Tumor Growth (2010, background): “It is a potent inducer of pAkt via PI3K and is not found in lung epithelial cells but is highly expressed in non–small-cell lung cancer (NSCLC”
Mechanisms of mitochondrial fission and fusion. (2013, background): “Several drugs, like Dynasore, inhibit both Dynamin and Drp1 (Macia et al. 2006), but there are also more selective drugs, like Mdivi-1, which only inhibit Drp1 homologs (Cassidy-Stone et al.”
Virus Entry by Endocytosis (2013, neutral): “For example, dynamin was originally noted for its role in severing clathrincoated vesicles from plasma membrane, but was then found to be indispensable for example in caveolar and some other clathrin-independent pathways [24, 71, 91].”
Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “Notable among them are Mdivi-1, 277 P110 278 , Dynasore 279 and DRP1i27.”
Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae (2011, methodology): “We used dynasore, an inhibitor of the dynamin GTPase that is involved in caveola internalization (Henley et al., 1998; Macia et al., 2006).”
Molecular mechanism and physiological functions of clathrin-mediated endocytosis (2011, background): “Preventing the recruitment of dynamin, or inhibiting its activity, arrests vesicle formation at the stage of clathrin coat formation or vesicle scissio”