Skewed maturation of memory HIV-specific CD8 T lymphocytes

By Patrick Champagne, G. Ogg, A. King, C. Knabenhans, Kim Ellefsen, M. Nobile, V. Appay, G. Rizzardi, S. Fleury, M. Lipp and 5 more. Nature, 2001

1,162 citations recorded by the source corpus.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/1a363b868156b98536646057003c0687769b7fee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. E. Wherry
2. Rafi Ahmed
3. S. Kaech
4. F. Sallusto
5. Mario Roederer
6. J. Wherry
7. Daniel C. Douek
8. R. Koup

In Virology

1. Daniel C. Douek
2. Mario Roederer
3. R. Koup
4. V. Appay
5. F. Sallusto
6. Rafi Ahmed

Citations in the corpus

• Seventeen-colour flow cytometry: unravelling the immune system (2004, background): “Ideal markers for immunophenotyping are proteins that are likely to be relevant in the life cycle of a cell type, such as the lymph-node homing molecules CD62L and CCR7 for naive T cell”
• Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction (2006, background): “Therefore, PD-1 hi HIV-specific CD8 + T cells in viremic individuals have a poorly differentiated phenotype (CD27 hi , CD28 lo , CD57 lo , CD127 lo , CCR7 − and CD45RA − ) previously reported to accumulate in dysfunctional HIV-specific CD8 + T cell”
• Phenotype and function of human T lymphocyte subsets: Consensus and issues (2008, background): “A potential link between failed T cell efficacy and an immature phenotype was initially suggested in that HIV-specific CD8 T cells show a CD271CCR72CD45RA2 phenotype in contrast to CMV-specific CD8 T cells (characterized by a CD272CCR72CD45RA1 phenotype) (61,62)”
• Emerging Concepts in the Immunopathogenesis of AIDS (2009, background): “Despite evidence that HIV- and SIV-specific CD8 T cells (CTLs) are involved in the control of viral replication (81–83), they have intrinsic functional defects— including decreased cytokine production, decreased proliferation, lack of polyfunctionality (described above), and lack of full effector di”
• Memory CD8 T-Cell Differentiation during Viral Infection (2004, background): “possible, however, that under certain conditions (76), especially chronic infections where antigen persists (1, 6, 26, 133),”
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “Further, HIV-specific CD8+ T cells are mainly IL-7RLo CD62LLo, but they express high amounts of CD27 (Appay et al., 2002; Boutboul et al., 2005; Champagne et al., 2001; Paiardini et al., 2005; Sabbaj et al., 2007; van Leeuwen et al., 2005; Wherry et al., 2006).”
• Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4+ and CD8+ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection (2001, background): “It has also been suggested that the functional differentiation of HIV-specific CD8 T cells may be impaired in HIV infection, such that the cytokine-producing cells present lack efficient cytolytic function (4, 11).”