Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

By L. Trautmann, L. Janbazian, N. Chomont, E. Said, S. Gimmig, B. Bessette, M. Boulassel, E. Delwart, H. Sepulveda, R. Balderas and 3 more. Nature Medicine, 2006

1,643 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/79d8cd6dc8f8c55162612d4ce38da626c3d91ed2

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In Epidemiology

1. B. Guy
2. W. Zou
3. E. Wherry

In Immunology

1. Lieping Chen
2. Arlene H. Sharpe
3. G. Freeman
4. S. Rosenberg
5. W. Zou
6. E. Wherry
7. Ton N. Schumacher
8. D. Pardoll

In Virology

1. Daniel C. Douek
2. Mario Roederer
3. R. Koup

Citations in the corpus

• Emerging Concepts in the Immunopathogenesis of AIDS (2009, neutral): “The efficacy of ART in 474 Douek · Roederer · Koup A nn u.”
• Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity (2010, background): “CD8+ T cells in humans chronically infected with HIV (Day et al., 2006; Petrovas et al., 2006; Trautmann et al., 2006), hepatitis B virus (Boettler et al.”
• Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production (2013, background): “…Vol. 210, No. 1 Article 151 Because PD-1, which was coexpressed with Ki-67, may define cells with reduced proliferation capacity (Day et al., 2006; Trautmann et al., 2006), the four sorted purified memory CD4 T cell populations were stimulated with anti-CD3 plus anti-CD28 antibodies and cell…”
• PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection (2006, result): “We did not see a correlation between plasma viral load and PD-1 expression on HIV-specifi c CD8+ T cells in this small group of subjects (unpublished data), although in larger cohort studies such an association has been clearly demonstrated (34, 35 ).”
• PD-1 and its ligands in tolerance and immunity. (2008, background): “Blocking PD1:PD-L interactions in vitro reverses the exhaustion of HIV-specific, HBV-specific (92), HCV-specific, and SIV-specific (97) CD8 and CD4 T cells and restores proliferation and cytokine production (23, 89, 90, 93).”