The immunobiology of cancer immunosurveillance and immunoediting.
By G. Dunn, Lloyd J. Old, Robert Schreiber. Immunity, 2004
2,941 citations recorded by the source corpus.
Subfields: Genetics, Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/1887ea8007070a0a7d143f8135005171b9db3829
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Citations in the corpus
- NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. (2008, background): “Immunoediting, also called immunoselection, is a process where immune responses select for variant tumor cells that have lost expression of specific molecules or antigens that are targeted by immune effector cells (Dunn et al., 2004).”
- The TRAIL apoptotic pathway in cancer onset, progression and therapy (2008, background): “Importantly, trimAb therapy also induced complete tumour rejection in a large proportion of mice bearing established MCA-induced sarcomas, despite the known heterogeneity of these tumours and their capacity to evade natural immunit”
- Galectins as modulators of tumour progression (2005, background): “Furthermore, tumour cells can release mediators believed to contribute to tumour cell evasion of the immune respons”
- New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape (2014, positive): “This dynamic process, whereby the immune system not only protects against cancer development but also shapes the character of emerging tumours, is composed of three phases — Elimination, Equilibrium and Escape — and has been extensively reviewed elsewhere [5,6].”
- NF-κB: linking inflammation and immunity to cancer development and progression (2005, background): “Although the immunosurveillance hypothesis has received some experimental suppor”
- Cancer despite immunosurveillance: immunoselection and immunosubversion (2006, background): “Cancer cells escape innate and adaptive immune responses — cancer immunosurveillance — by immunoselection (that is, selection of non-immunogenic tumour-cell variants, a process that is also known as immunoediting) or by immunosubversion (that is, active suppression of the immune response”
- Immunity, Inflammation, and Cancer (2010, neutral): “More evidence for tumor immunosurveillance and immunoediting comes from the presence of tumor infiltrating lymphocytes (both T and B lymphocytes) that recognize tumor antigens and the favorable prognosis for some patients whose tumors display increased infiltration with activated T cells (Dunn et al”
- Cancer-related inflammation (2008, background): “Cancer-related inflammation and adaptive immunity There is strong evidence from genetic studies of mouse models that cells of the adaptive immune system carry out surveillance and can eliminate nascent tumours (a process called immuno-editing”
- Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma (2007, neutral): “dtd" [ ]> Cancer immunoresistance and immune escap”
- Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma (2016, positive): “In this study we show that in addition to this critical role in the primary tumor, CD103+ DC have another crucial role to play in the priming of naive CD8+ T cells in the tu- 10 Cancer Cell 30, 1–13, August 8, 2016 mor dLN, which ultimately dictates the ability of CTLs to infiltrate the primary tumo”
- The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “In early stages of carcinogenesis, innate responses are beneficial and likely involved in the activation of effective surveillance by adaptive immunity as occurs in the elimination of these cells (53, 54).”