Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia

By Patrick C. Y. Woo, SusannaK P Lau, C. Chu, Kwok-Hung Chan, H. Tsoi, Yi Huang, Beatrice H. L. Wong, R. Poon, James J. Cai, W. Luk and 5 more. Journal of Virology, 2005

1,474 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/1864c1079c9f4dd526feb4111eadcd97ac688b9b

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Citations in the corpus

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission (2009, background): “Subsequent to the SARS epidemic, other coronaviruses capable of causing disease in humans, HCoV-NL63 and HCoV-HKU1, were identified from archived nasopharyngeal aspirates (140, 151).”
Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus (2012, methodology): “From our studies, it appears that bats and birds, the warm blooded flying vertebrates, are ideal hosts for the coronavirus gene source, bats for Alphacoronavirus and Betacoronavirus and birds for Gammacoronavirus and Deltacoronavirus, to fuel coronavirus evolution and dissemination.”
Coronaviruses: An Overview of Their Replication and Pathogenesis (2015, background): “HCoV-229E and HCoV-OC43 were isolated nearly 50 years ago [ 74 – 76 ], while HCoV-NL63 and HCoV-HKU1 have only recently been identifi ed following the SARS-CoV outbreak [ 77 , 78 ].”
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (2019, background): “Several new coronaviruses have now been identified, including three that infect humans: alphacoronavirus HCoV-NL63 [191] and betacoronaviruses HCoV-HKU1 and MERS-CoV [192, 193] .”
Sarbecovirus ORF6 proteins hamper induction of interferon signaling (2021, neutral): “Middle East respiratory syndrome (MERS)-CoV belongs to the subgenusMerbecovirus (van Boheemen et al., 2012; Zaki et al., 2012), whereas the human CoVs OC43 (McIntosh et al., 1967) and HKU1 (Woo et al., 2005) belong to the subgenus Embecovirus.”
Human Coronavirus: Host-Pathogen Interaction. (2019, background): “Two more HCoVs, HCoV-NL63 and HCoV-HKU1, were identified in 2004 and 2005, respectively (31, 127).”
The Molecular Biology of Coronaviruses (2006, background): “Most strikingly, the recently described HCoV-HKU1 genome contains two very significant segments of embedded leader sequence (Woo et al., 2005).”
Hosts and Sources of Endemic Human Coronaviruses (2018, background): “HCoV-HKU1 Human coronavirus HKU1 (for Hong Kong University) was detected in 2004 in a patient with viral pneumonia (Woo et al., 2005).”
ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia (2005, background): “Two previously recognized human coronaviruses (HCoV-OC43 and HCoV-229E) cause 30% of upper respiratory tract infections (14, 28), and, recently, two additional human coronaviruses, HCoV-NL63 (42) and HKU1 (46), were identified in association with bronchiolitis and pneumonia, respectively.”