ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia

By H. Jia, D. Look, Lei Shi, M. Hickey, L. Pewe, Jason Netland, M. Farzan, C. Wohlford-Lenane, S. Perlman, P. McCray. Journal of Virology, 2005

841 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues (2020, background): “In addition, it has been demonstrated that lung cells highly expressing ACE2 are more readily infected by SARS-CoV [19] .”
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status (2020, background): “ACE2, found in the lower respiratory tract of humans, is known as cell receptor for SARS-CoV [27] and regulates both the cross-species and human-to-human transmission [28].”
Coronavirus Structural Proteins and Virus Assembly (2008, background): “In respiratory epithelial cells, SARS-CoV and human coronavirus strain 229E preferentially enter and are exocytosed from the apical surface (78, 184, 192).”
Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus (2006, background): “hACE2 is expressed in human airway and alveolar epithelia (13), and SARS-CoV infects primary airway epithelial cells in vitro (14, 34).”
A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection (2020, background): “The adenoviral AdV-hACE2-GFP construct and defective virus preparation has been reported previously (22).”