Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission

By Rachel L. Graham, Ralph S. Baric. Journal of Virology, 2009

684 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/97d38f29f712e2767710c74a407e6c6f1c91ea06

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Citations in the corpus

Hosts and Sources of Endemic Human Coronaviruses (2018, background): “which the virus would have evolved human-compatible receptor tropism (Graham and Baric, 2010; Guan et al., 2003; Song et al., 2005; Wang et al., 2005; Xu et al., 2004).”
Molecular Evolution of Human Coronavirus Genomes (2016, neutral): “In CoVs, the S protein includes two functionally distinct units: the S1 region contains an Nterminal domain (NTD) and the receptor-binding domain (RBD, also referred to as C-terminal domain or CTD), whereas the S2 region includes the fusion peptide, two heptad repeats (HR1 and HR2), and the transmem”
Coronavirus Pathogenesis (2011, background): “The zoonotic origin of the SARS outbreak has recently been reviewed (Graham and Baric, 2010; Yip et al., 2009).”
Structure, Function, and Evolution of Coronavirus Spike Proteins (2016, background): “Coronaviruses are capable of adapting to new environments through mutation and recombination with relative ease and hence are programmed to alter host range and tissue tropism efﬁciently (12–14).”
The evolutionary dynamics of endemic human coronaviruses (2021, background): “Whereas interaction with the cellular receptor occurs via the S1 subunit at the RBD, membrane fusion occurs via the S2 subunit (Graham and Baric 2010).”
Zoonotic origins of human coronaviruses (2020, background): “In SARS-CoV, the RBD is in the 318 th to 510 th amino acids on the S1 fragment, which binds to the human ACE2 as well as its coreceptors for viral entry [75] .”
Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic (2020, background): “The key difficulty in inferring reliable evolutionary histories for coronaviruses is that their high recombination rate (Graham and Baric, 2010; Su et al., 2016) violates the assumption of standard phylogenetic approaches because different parts of the genome will have different origins.”
Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2 (2020, background): “In the S1 subunit, the receptor‐binding domain (RBD), spanning about 200 residues, consists of two subdomains: the core and external subdomains.14,15 The RBD core subdomain is responsible for the formation of S trimer particles.16 The external subdomain contains two exposed loops on the surface, whi”
Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1 (2015, background): “This is a new example of the modular nature of the spike 464 proteins of CoVs (29, 48), in which binding and entry of two CoVs in the same group 465 are initiated by different regions of the spike glycoprotein.”
Cross‐species transmission of the newly identified coronavirus 2019‐nCoV (2020, background): “Homologous recombination within viral structural proteins between coronaviruses from different hosts may be responsible for “cross‐species” transmission.(27) Information obtained from RSCU analysis provides some insights to the question of wildlife animal reservoir although it requires further valid”