Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

By A. Suzuki, R. Yamada, X. Chang, S. Tokuhiro, T. Sawada, Masakatsu Suzuki, Miyuki Nagasaki, Makiko Nakayama-Hamada, Reimi Kawaida, Mitsuru Ono and 15 more. Nature Genetics, 2003

1,118 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Rheumatology

View Paper: https://www.semanticscholar.org/paper/17e7126257e472c3518a0b97430165999433a783

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In Rheumatology

1. Gary S. Firestein
2. I. McInnes
3. David Altshuler
4. Georg Schett
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Citations in the corpus

• Immunopathogenesis of rheumatoid arthritis (2017, positive): “An extended PADI4 haplotype prolongs its mRNA stability and could, therefore, increase peptide citrullination (Suzuki et al., 2003).”
• An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis (2003, background): “Although incomplete, this project has previously identified the gene encoding peptidylarginine deiminase type IV as being associated with susceptibility to rheumatoid arthriti”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “The involvement of PAD in the pathogenesis of various autoimmune diseases such as rheumatoid arthritis has been established (Suzuki et al., 2003; Vossenaar et al., 2003a; Lundberg et al., 2005; Yamada et al., 2005).”
• A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. (2004, background): “Although interesting associations have been reported (Suzuki et al. 2003; Tokuhiro et al. 2003), only alleles at the HLA-DRB1 locus have consistently demonstrated both linkage and association (Seldin et al 1999).”
• High density genetic mapping identifies new susceptibility loci for rheumatoid arthritis (2012, background): “Three of the new loci confirmed here in samples of European ancestry have been previously associated with rheumatoid arthritis in either samples of east Asian ancestry ( PADI4 and ARID5B ) or when using a multiethnic approach ( IKZF3 ) 9–11 .”
• Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. (2005, methodology): “Specific alleles at PADI4 (Suzuki et al. 2003), CTLA4 (Rodriguez et al. 2002; Vaidya et al. 2002), IL4 (Cantagrel et al. 1999; Maksymowych et al. 2002), SLC22A4 (Tokuhiro et al. 2003), MIF (Barton et al. 2003), and TNFRSF1B (Barton et al. 2001; Dieude et al. 2002; Kyogoku et al. 2003) have been…”
• Five years of GWAS discovery. (2012, background): “The finding that PADI4 (MIM 605347) is associated with RA focused research interest on the role of anti-citrullinated peptide antibodies (ACPAs) and disease.(48) PADI4 is involved in the citrullination of peptides against which ACPAs develop.”
• Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality (2011, neutral): “It is expressed by various leukocytes(43) including neutrophils(44) and immuno-modulatory functions have been ascribed to PAD4 activity.(45,46) Like other PAD isotypes, PAD4 is a Ca2þ dependent enzyme, but only PAD4 possesses a classical nuclear localization signal (NLS).”