Five years of GWAS discovery.

By Peter M. Visscher, M. Brown, Mark I. McCarthy, Jian Yang. American Journal of Human Genetics, 2012

2,481 citations recorded by the source corpus.

Subfields: Computer Vision and Pattern Recognition, Public Health, Environmental and Occupational Health, Signal Processing

View Paper: https://www.semanticscholar.org/paper/8e95231c5cfdd1699b98445d0f56e887eed8b5bb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computer Vision and Pattern Recognition

1. Joshua Charles Denny
2. Jianzhu Ma

In Public Health, Environmental and Occupational Health

1. Wei-Qi Wei
2. George Davey Smith
3. F. S. Collins
4. Mark I. McCarthy
5. Joshua Charles Denny

In Signal Processing

1. Roded Sharan
2. Joshua Charles Denny
3. Jianzhu Ma

Citations in the corpus

• Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants (2013, methodology): “To correlate chromatin features with the location of type 2 diabetes (T2D) genetic risk variants and with gene expression, we conducted high-throughput sequencing coupled to ChIP (ChIPseq) and mRNA samples (RNA-seq) in human pancreatic islets, a cell type relevant to diabetes and to quantitative tra”
• Polygenic prediction of weight and obesity trajectories from birth to adulthood (2019, background): “This paradigm is similar to other complex diseases in which polygenic inheritance, involving many common genetic variants, accounts for the majority of inherited susceptibility (Golan et al., 2014; Purcell et al., 2009; Visscher et al., 2012; Yang et al., 2011; Zhu et al., 2015).”
• Impact of genetic polymorphisms on human immune cell gene expression (2018, neutral): “GWAS variants were linked to cell types where their effects are most pronounced”
• Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics (2016, background): “However, deriving biological knowledge from these associations is often challenging[1,2].”
• Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry (2018, methodology): “We derived a more detailed version of equation (1) in Supplementary Note 3.”
• Detection and interpretation of shared genetic influences on 42 human traits (2016, neutral): “As the number of reliable associations between genetic variants and various phenotypes has grown over the last decade 9 , these issues have received increasing attention.”