Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

By M. Iijima, P. Devreotes. Cell, 2002

713 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/17972863857f68bfbef95a3cd036c43711de8a7a

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In Genetics

T. Balla

In Molecular Biology

Citations in the corpus

The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, neutral): “has been shown to localize at the trailing edge of migrating cell”
Guidance of primordial germ cell migration by the chemokine SDF-1. (2002, methodology): “Using the available genetic and moto et al., 2002; Iijima and Devreotes, 2002).”
Dynamic Partitioning into Lipid Rafts Controls the Endo-Exocytic Cycle of the αL/β2 Integrin, LFA-1, during Leukocyte Chemotaxis (2005, background): “By being recruited to the posterior edge of migrating cells, PTEN contributes to establishing an internal anterior-posterior gradient of the phosphatidylinositol 3,4,5-phosphate lipid messenger, which is required to impart directionality to the moving cell (Funamoto et al., 2002; Iijima and Devreote”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Importantly, the PtdIns(3,4,5)P3 phosphatase PTEN was found to localize to the trailing end of the cell (677), and its deletion increases overall PtdIns(3,4,5)P3 levels and dissipates the PtdIns(3,4,5)P3 gradient interfering with efficient chemotaxis (677).”
Chemotaxis: signalling the way forward (2004, neutral): “pl?P60484">PTEN (phosphatase and tensin homologue”
Directional Sensing Requires G-Mediated PAK1 and PIX-Dependent Activation of Cdc42 (2003, background): “The staining pattern of CBD was also polarizedulation (Funamoto et al., 2002; Iijima and Devreotes, 2002).”
Cell migration: Rho GTPases lead the way. (2004, background): “Elegant studies in Dicytostelium have shown that the localization of PI 3-kinase at the front is coupled to a restricted distribution of its antagonist, the PI(3,4,5)P3 phosphatase PTEN, at the rear, and that this is essential for chemotaxis (Funamoto et al., 2002; Iijima and Devreotes, 2002).”