Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells.

By G. Rajkowska. Biological Psychiatry, 2000

837 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Social Psychology

View Paper: https://www.semanticscholar.org/paper/16a3ed934959b5fbbbe230191d7c7ba9643f2346

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In Social Psychology

Citations in the corpus

Major depression following traumatic brain injury. (2004, background): “Brain atrophic changes can be observed among patients with chronic mood disorders.(30,66,67) We analyzed the effect of a history of anxiety or depressive disorders on frontal lobe volumetric measures.”
A Research Agenda For DSM-V (2002, background): “cell number and packing density have been reported in postmortem brains of subjects with a history of major depressive disorder and bipolar disorder (Cotter et al. 2001; Ongur et al. 1998; Rajkowska 2000; Rajkowska et al. 1999).”
Decreased serum brain-derived neurotrophic factor levels in major depressed patients. (2002, background): “, 1997) these findings lend further support to the neuronal morphologic approach to depression which proposes that alteration in the expression of neurotrophic factors could be responsible for disturbed neural plasticity (Duman et al., 1997; Sheline et al., 1996; Rajkowska, 2000).”
Neuroimaging studies of mood disorders. (2000, background): “If the reduction of astroglia found in mood disorders (Rajkowska 2000) impairs the efficiency of glutamate transport, it is conceivable that glutamate concentrations may increase.”
The cellular neurobiology of depression (2001, background): “In the latter regions recent morphometric MRI and post mortem investigations have also demonstrated abnormalities of brain structure that persist independently of mood state and may contribute to the corresponding abnormalities of metabolic activit”
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “One region is the prefrontal cortex which loses volume in depressive disorder [401], autopsy studies also revealed loss of volume and glial cells as well as neuronal density in both unipolar and bipolar depression [402–404].”
When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. (2011, background): “Unlike the hippocampus, the frontal cortex of patients with major depression has been found to exhibit neuropathologic abnormalities, including loss of neuronal elements, especially glia (76).”
Towards a glutamate hypothesis of depression (2011, background): “…and glutamine in patients with mood disorders, reduced numbers and density of glial cells have been reported in a number of postmortem studies (Rajkowska, 2000; Rajkowska et al., 1999, 2001; Bowley et al., 2002; Miguel-Hidalgo et al., 2002; Webster et al., 2001; Cotter et al., 2001;…”
The stress system in the human brain in depression and neurodegeneration. (2005, background): “Postmortem studies have further provided morphological evidence for the involvement of the prefrontal cortex in depression; cell loss takes place in the prefrontal cortex, while cell atrophy occurs in the dorsolateral and orbitofrontal cortex (Rajkowska, 2000).”
Brain on stress: How the social environment gets under the skin (2012, result): “Although there does not seem to be neuronal loss, there is evidence for glial cell loss and smaller neuronal cell nuclei (56, 110), which is consistent with a shrinking of the dendritic tree described above after chronic stress.”