The cellular neurobiology of depression

By Husseini K. Manji, Wayne C. Drevets, Dennis S. Charney. Nature Medicine, 2001

1,169 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/a482f7f05e1d6c795752f688f9e5ceb95970ef5f

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In Behavioral Neuroscience

In Biological Psychiatry

In Developmental Neuroscience

Citations in the corpus

Structural Plasticity and Hippocampal Function (2010, background): “…of these is beyond the scope of this review, adult neurogenesis and other forms of structural plasticity have been implicated in addiction, schizophrenia, Alzheimer’s, and epilepsy (reviewed in Burke & Barnes 2006, Eisch et al. 2008, Manji et al. 2001, Russo et al. 2009, Swann et al. 2000).”
Major depression following traumatic brain injury. (2004, background): “Brain atrophic changes can be observed among patients with chronic mood disorders.(30,66,67) We analyzed the effect of a history of anxiety or depressive disorders on frontal lobe volumetric measures.”
Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. (2009, neutral): “Major depression is a chronic, recurring and potentially life threatening mental illness and will be the primary cause of disability in the world by the year 2020 estimated by the World Health Organization [107].”
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, background): “Despite much excitement generated by recent advances in the knowledge of brain development and function, the mechanisms underlying the pathogenesis of depression, as well as its amelioration by antidepressant (AD) treatment, remain poorly understood (Manji et al., 2001; Nestler et al., 2002).”
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states (2002, methodology): “In an important hypothesis by Nestler's group, and in the excellent work of Manji et al , abnormalities in growth factors and in other intracellular transduction mediators may play a highly significant role in the neurodegeneration in depressed patients”
Adult hippocampal neurogenesis in depression (2007, background): “The heterogeneity of depression implies that multiple neural substrates and mechanisms contribute to its etiolog”
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects (2003, background): “Antidepressant drugs acutely facilitate signaling of serotonin or norepinephrine by inhibiting their reuptake to presynaptic terminals (tricyclic antidepressants, such as imipramine) or by inhibiting their catabolism (monoamine oxidase inhibitors), or binding to serotonin autoreceptors (for review, ”