Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
By Qi Chen, M. Espey, M. Krishna, James B. Mitchell, C. Corpe, G. Buettner, E. Shacter, M. Levine. Proceedings of the National Academy of Sciences of the United States of America, 2005
1,045 citations recorded by the source corpus.
Subfields: Health, Toxicology and Mutagenesis, Materials Chemistry, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/15a5f9b65499e6b73df5418a0b1598cf57a1b201
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In Materials Chemistry
In Nutrition and Dietetics
Citations in the corpus
- Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. (2007, background): “They showed, for instance, that a concentration of 50 lM of H2O2 induced more percentage of cell death in Burkitt’s lymphoma cells than 250 lM in normal lymphocytes and normal monocytes [74].”
- Vitamin C physiology: the known and the unknown and Goldilocks (2016, neutral): “Animal studies show that only these pharmacologic concentrations of ascorbate produce ascorbate radical and hydrogen peroxide in the extracellular fluid (Fig 8) (Chen et al., 2005).”
- Dietary polyphenols: good, bad, or indifferent for your health? (2007, background): “Ascorbate also oxidizes in DMEM to make H2O2, but mixtures of ascorbate and flavonoids generate less H2O2 om https://academic.oup.com/cardiovascres/article-abstract/73/2/341/48699 018 than would be expected from the rate of its generation by either compound alone [110].”
- Ascorbic acid: Chemistry, biology and the treatment of cancer (2012, background): “[9,11] have demonstrated that some cancer cells have increased sensitivity to ascorbate-induced cytotoxicity compared to normal cells.”
- Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice (2008, methodology): “In our initial in vitro experiments, we observed hydrogen peroxide (H2O2)-dependent cytotoxicity after ascorbate exposure (EC50 4 mM) in five cancer cell lines, whereas normal cells were resistant (4).”