Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
By Qi Chen, M. Espey, Andrew Y. Sun, Chaya Pooput, K. Kirk, M. Krishna, Deena Beneda Khosh, J. Drisko, M. Levine. Proceedings of the National Academy of Sciences of the United States of America, 2008
829 citations recorded by the source corpus.
Subfields: Materials Chemistry, Nutrition and Dietetics, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/9f295521e75f7f425d87f990a548e8d9a0de22f0
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In Nutrition and Dietetics
Citations in the corpus
- Ascorbic acid: Chemistry, biology and the treatment of cancer (2012, background): “, twice daily) significantly decreased the rate of tumor growth [11,12,164] (Table 4).”
- Vitamin C physiology: the known and the unknown and Goldilocks (2016, neutral): “Pro oxidant Target Effect DNA DNA damage (Podmore et al., 1998) Lipid hydroperoxidase Decomposition of lipid peroxidase leading to DNA damage (Lee et al., 2001) Downstream targets of hydrogen peroxide Damage to cancer cells (Chen et al., 2007) (Chen et al., 2008) (Parrow et al., 2013) Oral Dis.”
- Fundamentals of cancer metabolism (2016, background): “Thus, high doses of vitamin C diminish the tumorigenesis of colorectal tumors that harbor oncogenicKRASmutations and express high levels ofGLUT1bydepleting the NADPH and GSH pools and consequently increasing ROS levels to induce cancer cell death (179, 180).”