Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.

By H. Yoshihara, F. Arai, Kentarou Hosokawa, T. Hagiwara, K. Takubo, Yuka Nakamura, Yumiko Gomei, H. Iwasaki, S. Matsuoka, K. Miyamoto and 3 more. Cell Stem Cell, 2007

764 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Hematology

View Paper: https://www.semanticscholar.org/paper/14987ceb706e06572a953b9c9fe068e1b5b0e499

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In Cardiology and Cardiovascular Medicine

P. Bonaldo

In Hematology

Citations in the corpus

Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2 mediated regeneration of sinusoidal endothelial cells (2009, neutral): “Although the phenotypic and functional attributes of the OBN are well defined (Arai et al., 2004; Calvi et al., 2003; Hattori et al., 2002; Heissig et al., 2002; Kiel et al., 2005; Yoshihara et al., 2007; Zhang et al., 2003), the identity of the vascular compartments in BM contributing to hematopoie”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “HSCs share an important relationship with osteablasts and other stromal elements of the bone marrow niche critical to their maintenance and protection (Jones and Wagers, 2008; Li and Xie, 2005; Qian et al., 2007; Yoshihara et al., 2007).”
Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “In this endosteal niche, osteoblasts have been shown to influence HSC pool by regulating stem cell number [117,126], and to maintain HSC quiescence by releasing several signals, such as angiopoietin, thrombopoietin, and stromal cell-derived factor-1 [54,127], as well as HSC self-renewal via Notch ac”
Mechanisms of stem cell self-renewal. (2009, background): “…of mouse HSCs depends on a series of stem cell–extrinsic factors in the bone marrow including Steel factor (Thoren et al. 2008), CXCL12 (Nie et al. 2008, Sugiyama et al. 2006), Thrombopoietin (Qian et al. 2007, Yoshihara et al. 2007), and Angiopoietin-1 (Arai et al. 2004, Puri & Bernstein 2003).”
Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “Recent findings suggest that HSCs are maintained in a quiescent state through interaction with thrombopoietin-producing osteoblasts (Yoshihara et al., 2007).”
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, neutral): “Mutations in any of these genes lead to increased HSC cycling followed by loss of stem cell activity probably due to exhaustion (Qian et al., 2007; Thoren et al., 2008; Yoshihara et al., 2007).”