Autosis and autophagic cell death: the dark side of autophagy

By Yang Liu, Beth Levine. Cell Death and Differentiation, 2014

681 citations recorded by the source corpus.

It is controversial whether cells truly die via autophagy or whether — in dying cells — autophagy is merely an innocent bystander or a well-intentioned ‘Good Samaritan’ trying to prevent inevitable cellular demise. However, there is increasing evidence that the genetic machinery of autophagy may be essential for cell death in certain settings. We recently identified a novel form of autophagy gene-dependent cell death, termed autosis, which is mediated by the Na+,K+-ATPase pump and has unique morphological features. High levels of cellular autophagy, as occurs with treatment with autophagy-inducing peptides, starvation, or in vivo during certain types of ischemia, can trigger autosis. These findings provide insights into the mechanisms and strategies for prevention of cell death during extreme stress conditions.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f96a632cae12a63c558b51fd08970c3b69de1e63

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Guy C. Brown
2. R. Kang
3. Michael Coleman
4. H. J. Zeh
5. Michael Lotze
6. V. Borutaite
7. M. Fricker
8. A. Tolkovsky

In Epidemiology

1. D. Tang
2. R. Kang
3. Soheila Karimi-Abdolrezaee
4. Guy C. Brown
5. Michael Coleman
6. H. J. Zeh
7. Michael Lotze
8. V. Borutaite

In Molecular Biology

1. D. Tang
2. R. Kang
3. H. J. Zeh
4. Xinxin Song
5. Guy C. Brown
6. Michael Coleman
7. Xiaofang Sun
8. Michael Lotze

Citations in the corpus

• Neuronal Cell Death. (2018, positive): “One example was reported by Levine and colleagues, who found that overexpression of a peptide from Beclin-1 (ATG6) promoted excessive autophagy and this was sufficient for autophagy-dependent death, which they termed “autosis” (422, 423).”
• Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Dysregulation of autophagy contributes to neuronal loss (174, 180).”
• Autophagy promotes ferroptosis by degradation of ferritin (2016, background): “In some cases, excessive and impaired autophagy may contribute to cell death.(3) Thus, defining the context-dependent function of autophagy in the regulation of cell death is important.”